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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TFB1M

Summary for TFB1M

Gene information	Gene symbol	TFB1M
	Ensembl ID	ENSG00000029639
	Entrez ID	51106
	Gene name	transcription factor B1, mitochondrial
	Synonyms	CGI-75\|mtTFB
	Gene type	protein_coding
	UniProtAcc	Q8WVM0

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Dataset with differentially expressed gene: TFB1M

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.312131	0.00e+00

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Expression of TFB1M in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TFB1M

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TFB1M

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TFB1M	hsa-miR-3686	98.2289	NM_016020
TFB1M	hsa-miR-144-3p	96.8246	NM_016020
TFB1M	hsa-miR-4688	96.5381	NM_016020
TFB1M	hsa-miR-6743-5p	95.663	NM_016020
TFB1M	hsa-miR-6789-5p	94.0508	NM_016020
TFB1M	hsa-miR-4662a-3p	91.8392	NM_016020
TFB1M	hsa-miR-4491	90.3598	NM_016020
TFB1M	hsa-miR-4657	90.3598	NM_016020
TFB1M	hsa-miR-4422	88.2346	NM_016020
TFB1M	hsa-miR-584-3p	87.9639	NM_016020
TFB1M	hsa-miR-153-5p	87.8522	NM_016020
TFB1M	hsa-miR-6885-3p	87.1426	NM_016020
TFB1M	hsa-miR-143-5p	86.4579	NM_016020
TFB1M	hsa-miR-4796-3p	86.2211	NM_016020
TFB1M	hsa-miR-6833-5p	86.0992	NM_016020
TFB1M	hsa-miR-4433b-3p	85.6761	NM_016020
TFB1M	hsa-miR-212-5p	85.6161	NM_016020
TFB1M	hsa-miR-1250-3p	85.228	NM_016020
TFB1M	hsa-miR-548aw	84.9664	NM_016020
TFB1M	hsa-miR-3065-3p	84.8825	NM_016020
TFB1M	hsa-miR-1913	84.8729	NM_016020
TFB1M	hsa-miR-1284	84.6837	NM_016020
TFB1M	hsa-miR-4774-3p	84.317	NM_016020
TFB1M	hsa-miR-6801-5p	84.1925	NM_016020
TFB1M	hsa-miR-10393-3p	84.1925	NM_016020
TFB1M	hsa-miR-6733-3p	84.1673	NM_016020
TFB1M	hsa-miR-6085	83.9959	NM_016020
TFB1M	hsa-miR-6813-5p	83.9959	NM_016020
TFB1M	hsa-miR-6783-3p	82.9222	NM_016020
TFB1M	hsa-miR-4661-3p	82.0236	NM_016020
TFB1M	hsa-miR-6742-3p	81.9432	NM_016020
TFB1M	hsa-miR-1285-3p	80.4747	NM_016020
TFB1M	hsa-miR-5189-5p	80.4747	NM_016020
TFB1M	hsa-miR-122-5p	80.0855	NM_016020

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Motifs and transcription factors (TFs) regulating TFB1M

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TFB1M	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
TFB1M	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
TFB1M	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
TFB1M	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."