Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TFAP2C

Summary for TFAP2C

Gene information	Gene symbol	TFAP2C
	Ensembl ID	ENSG00000087510
	Entrez ID	7022
	Gene name	transcription factor AP-2 gamma
	Synonyms	AP2-GAMMA\|ERF1\|hAP-2g\|TFAP2G
	Gene type	protein_coding
	UniProtAcc	Q92754

Top

Dataset with differentially expressed gene: TFAP2C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.312001	1.74e-14

Top

Expression of TFAP2C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TFAP2C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TFAP2C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TFAP2C	hsa-miR-3613-3p	98.2847	NM_003222
TFAP2C	hsa-miR-10b-5p	97.5568	NM_003222
TFAP2C	hsa-miR-10a-5p	97.5568	NM_003222
TFAP2C	hsa-miR-8485	95.3416	NM_003222
TFAP2C	hsa-miR-141-3p	94.6448	NM_003222
TFAP2C	hsa-miR-200a-3p	94.6448	NM_003222
TFAP2C	hsa-miR-3941	93.3035	NM_003222
TFAP2C	hsa-miR-1255b-2-3p	92.1468	NM_003222
TFAP2C	hsa-miR-29c-3p	91.1046	NM_003222
TFAP2C	hsa-miR-29b-3p	91.1046	NM_003222
TFAP2C	hsa-miR-29a-3p	91.1046	NM_003222
TFAP2C	hsa-miR-548at-5p	90.3729	NM_003222
TFAP2C	hsa-miR-7151-3p	88.9648	NM_003222
TFAP2C	hsa-miR-603	88.4283	NM_003222
TFAP2C	hsa-miR-6770-5p	88.3355	NM_003222
TFAP2C	hsa-miR-5682	87.9299	NM_003222
TFAP2C	hsa-miR-1237-3p	84.561	NM_003222
TFAP2C	hsa-miR-548ap-3p	84.0114	NM_003222
TFAP2C	hsa-miR-548t-3p	84.0114	NM_003222
TFAP2C	hsa-miR-548aa	84.0114	NM_003222
TFAP2C	hsa-miR-3619-5p	81.8948	NM_003222
TFAP2C	hsa-miR-12136	81.1719	NM_003222
TFAP2C	hsa-miR-616-5p	80.8255	NM_003222
TFAP2C	hsa-miR-373-5p	80.8255	NM_003222
TFAP2C	hsa-miR-371b-5p	80.8255	NM_003222

Page: 1

Top

Motifs and transcription factors (TFs) regulating TFAP2C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TFAP2C	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
TFAP2C	transfac_pro__M04844	MAX (directAnnotation).
TFAP2C	swissregulon__hs__FOXD3	FOXD3 (directAnnotation).
TFAP2C	tfdimers__MD00456	E2F6; OVOL2 (directAnnotation).
TFAP2C	taipale_tf_pairs__TEAD4_ELK1_RGAATSCGGAAGYN_CAP	ELK1; TEAD4 (directAnnotation).
TFAP2C	metacluster_77.11	SOX12 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."