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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TFAP2B

Summary for TFAP2B

Gene information	Gene symbol	TFAP2B
	Ensembl ID	ENSG00000008196
	Entrez ID	7021
	Gene name	transcription factor AP-2 beta
	Synonyms	AP-2beta\|AP2-B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TFAP2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.98248	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.256995	0.00e+00

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Expression of TFAP2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TFAP2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TFAP2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TFAP2B	hsa-miR-3133	99.0784	NM_003221
TFAP2B	hsa-miR-361-5p	98.9547	NM_003221
TFAP2B	hsa-miR-6875-3p	98.1513	NM_003221
TFAP2B	hsa-miR-320d	96.6574	NM_003221
TFAP2B	hsa-miR-4429	96.6574	NM_003221
TFAP2B	hsa-miR-320a-3p	96.6574	NM_003221
TFAP2B	hsa-miR-320c	96.6574	NM_003221
TFAP2B	hsa-miR-320b	96.6574	NM_003221
TFAP2B	hsa-miR-9-3p	96.3886	NM_003221
TFAP2B	hsa-miR-513a-5p	96.3533	NM_003221
TFAP2B	hsa-miR-9985	96.3533	NM_003221
TFAP2B	hsa-miR-27a-3p	96.3533	NM_003221
TFAP2B	hsa-miR-27b-3p	96.3533	NM_003221
TFAP2B	hsa-miR-149-3p	94.295	NM_003221
TFAP2B	hsa-miR-6883-5p	94.295	NM_003221
TFAP2B	hsa-miR-4728-5p	94.192	NM_003221
TFAP2B	hsa-miR-6785-5p	94.192	NM_003221
TFAP2B	hsa-miR-7111-5p	93.5133	NM_003221
TFAP2B	hsa-miR-6870-5p	93.5133	NM_003221
TFAP2B	hsa-miR-5698	93.5133	NM_003221
TFAP2B	hsa-miR-4723-5p	93.5133	NM_003221
TFAP2B	hsa-miR-2115-3p	92.7808	NM_003221
TFAP2B	hsa-miR-1178-5p	91.7798	NM_003221
TFAP2B	hsa-miR-4476	90.6224	NM_003221
TFAP2B	hsa-miR-6876-5p	90.6224	NM_003221
TFAP2B	hsa-miR-92a-2-5p	90.0166	NM_003221
TFAP2B	hsa-miR-6757-3p	89.4384	NM_003221
TFAP2B	hsa-miR-297	87.2397	NM_003221
TFAP2B	hsa-miR-1277-5p	87.2212	NM_003221
TFAP2B	hsa-miR-3175	87.0368	NM_003221
TFAP2B	hsa-miR-374a-3p	86.8144	NM_003221
TFAP2B	hsa-miR-3145-3p	86.7727	NM_003221
TFAP2B	hsa-miR-577	86.4132	NM_003221
TFAP2B	hsa-miR-4282	86.0029	NM_003221
TFAP2B	hsa-miR-302f	85.8979	NM_003221
TFAP2B	hsa-miR-1248	85.1111	NM_003221
TFAP2B	hsa-miR-644a	84.7988	NM_003221
TFAP2B	hsa-miR-452-5p	84.6628	NM_003221
TFAP2B	hsa-miR-892c-3p	84.6628	NM_003221
TFAP2B	hsa-miR-4676-3p	84.6628	NM_003221
TFAP2B	hsa-miR-491-5p	84.355	NM_003221
TFAP2B	hsa-miR-4257	83.8057	NM_003221
TFAP2B	hsa-miR-4503	83.6952	NM_003221
TFAP2B	hsa-miR-6868-3p	83.6041	NM_003221
TFAP2B	hsa-miR-4516	83.3072	NM_003221
TFAP2B	hsa-miR-6867-5p	82.9107	NM_003221
TFAP2B	hsa-miR-3074-3p	82.8954	NM_003221
TFAP2B	hsa-miR-3059-5p	82.0793	NM_003221
TFAP2B	hsa-miR-204-5p	81.5077	NM_003221
TFAP2B	hsa-miR-211-5p	81.5077	NM_003221

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Motifs and transcription factors (TFs) regulating TFAP2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TFAP2B	hdpi__FOXM1	FOXM1 (directAnnotation).
TFAP2B	transfac_pro__M06074	ZNF732 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."