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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TET2

Summary for TET2

Gene information	Gene symbol	TET2
	Ensembl ID	ENSG00000168769
	Entrez ID	54790
	Gene name	tet methylcytosine dioxygenase 2
	Synonyms	FLJ20032\|KIAA1546
	Gene type	protein_coding
	UniProtAcc	Q6N021

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Dataset with differentially expressed gene: TET2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.340923	7.27e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.266522	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.384792	1.14e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.445178	0.00e+00

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Expression of TET2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TET2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
TET2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating TET2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TET2	hsa-miR-5011-5p	100	NM_001127208
TET2	hsa-miR-190a-3p	99.9999	NM_001127208
TET2	hsa-miR-1297	99.9069	NM_001127208
TET2	hsa-miR-26a-5p	99.6596	NM_001127208
TET2	hsa-miR-26b-5p	99.6596	NM_001127208
TET2	hsa-miR-548x-3p	99.5721	NM_001127208
TET2	hsa-miR-548aj-3p	99.5721	NM_001127208
TET2	hsa-miR-101-3p	99.5188	NM_001127208
TET2	hsa-miR-144-3p	99.3534	NM_001127208
TET2	hsa-miR-4465	99.3503	NM_001127208
TET2	hsa-miR-548aq-3p	99.1364	NM_001127208
TET2	hsa-miR-548am-3p	99.1364	NM_001127208
TET2	hsa-miR-548ae-3p	99.1364	NM_001127208
TET2	hsa-miR-548ah-3p	99.1364	NM_001127208
TET2	hsa-miR-548j-3p	99.1364	NM_001127208
TET2	hsa-miR-10527-5p	97.9598	NM_001127208
TET2	hsa-miR-4795-3p	97.685	NM_017628
TET2	hsa-miR-29a-3p	96.9099	NM_001127208
TET2	hsa-miR-29c-3p	96.9099	NM_001127208
TET2	hsa-miR-29b-3p	96.9099	NM_001127208
TET2	hsa-miR-130b-5p	96.2246	NM_017628
TET2	hsa-miR-3065-3p	96.1175	NM_001127208
TET2	hsa-miR-3613-3p	95.7351	NM_017628
TET2	hsa-miR-3148	95.6945	NM_017628
TET2	hsa-miR-302e	95.6262	NM_001127208
TET2	hsa-miR-196a-1-3p	95.1139	NM_017628
TET2	hsa-miR-5680	95.0848	NM_017628
TET2	hsa-miR-4422	94.4659	NM_001127208
TET2	hsa-miR-126-5p	94.0559	NM_017628
TET2	hsa-miR-548av-3p	93.8008	NM_017628
TET2	hsa-miR-4477a	93.6382	NM_001127208
TET2	hsa-miR-3685	93.5241	NM_001127208
TET2	hsa-miR-302a-3p	93.4945	NM_001127208
TET2	hsa-miR-302b-3p	93.4945	NM_001127208
TET2	hsa-miR-302c-3p	93.4945	NM_001127208
TET2	hsa-miR-302d-3p	93.4945	NM_001127208
TET2	hsa-miR-5006-3p	93.4893	NM_017628
TET2	hsa-miR-4755-5p	93.4893	NM_017628
TET2	hsa-miR-590-3p	93.2994	NM_017628
TET2	hsa-miR-3529-3p	92.9519	NM_017628
TET2	hsa-miR-568	92.8887	NM_017628
TET2	hsa-miR-548an	92.8819	NM_017628
TET2	hsa-miR-1227-3p	92.8089	NM_017628
TET2	hsa-miR-520e-3p	92.775	NM_001127208
TET2	hsa-miR-520b-3p	92.775	NM_001127208
TET2	hsa-miR-372-3p	92.775	NM_001127208
TET2	hsa-miR-520a-3p	92.775	NM_001127208
TET2	hsa-miR-520d-3p	92.775	NM_001127208
TET2	hsa-miR-520c-3p	92.775	NM_001127208
TET2	hsa-miR-373-3p	92.775	NM_001127208

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Motifs and transcription factors (TFs) regulating TET2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TET2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TET2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
TET2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TET2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TET2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TET2	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
TET2	transfac_pro__M12686	ZBTB10 (directAnnotation).
TET2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TET2	metacluster_143.14	ZNF320 (directAnnotation).
TET2	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
TET2	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
TET2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TET2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
TET2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
TET2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TET2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
TET2	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
TET2	transfac_pro__M04617	ZBTB7A (directAnnotation).
TET2	transfac_pro__M01973	PLAG1 (directAnnotation).
TET2	metacluster_151.2	ZNF23 (directAnnotation).
TET2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TET2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TET2	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
TET2	cisbp__M01864	EGR1 (inferredBy_Orthology).
TET2	tfdimers__MD00391	KLF4 (directAnnotation).
TET2	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
TET2	transfac_pro__M05479	ZNF580 (directAnnotation).
TET2	tfdimers__MD00151	CHURC1 (directAnnotation).
TET2	transfac_pro__M04817	ZBTB33 (directAnnotation).
TET2	cisbp__M00139	ZNF281 (inferredBy_Orthology).
TET2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TET2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
TET2	transfac_public__M00491	PATZ1 (directAnnotation).
TET2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TET2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
TET2	jaspar__MA1122.1	TFDP1 (directAnnotation).
TET2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
TET2	transfac_pro__M01253	CNOT3 (directAnnotation).
TET2	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
TET2	cisbp__M00968	MTF2 (directAnnotation).
TET2	tfdimers__MD00038	TFAP2C (directAnnotation).
TET2	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
TET2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TET2	transfac_pro__M01199	TRIM28 (directAnnotation).
TET2	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
TET2	metacluster_3.14	WT1; WT1 (directAnnotation).
TET2	transfac_pro__M12697	ZNF142 (directAnnotation).
TET2	metacluster_84.2	RARA (directAnnotation).
TET2	transfac_pro__M01122	ZNF219 (directAnnotation).
TET2	transfac_pro__M07387	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."