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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TET1

Summary for TET1

Gene information	Gene symbol	TET1
	Ensembl ID	ENSG00000138336
	Entrez ID	80312
	Gene name	tet methylcytosine dioxygenase 1
	Synonyms	bA119F7.1\|CXXC6\|KIAA1676\|LCX
	Gene type	protein_coding
	UniProtAcc	Q8NFU7

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Dataset with differentially expressed gene: TET1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.32949	0.00e+00

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Expression of TET1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TET1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TET1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TET1	hsa-miR-767-5p	99.945	NM_030625
TET1	hsa-miR-498-3p	99.9074	NM_030625
TET1	hsa-miR-29c-3p	99.7933	NM_030625
TET1	hsa-miR-29b-3p	99.7933	NM_030625
TET1	hsa-miR-29a-3p	99.7933	NM_030625
TET1	hsa-miR-1297	99.4804	NM_030625
TET1	hsa-miR-3924	98.812	NM_030625
TET1	hsa-miR-26a-5p	98.7846	NM_030625
TET1	hsa-miR-26b-5p	98.7846	NM_030625
TET1	hsa-miR-4465	98.2957	NM_030625
TET1	hsa-miR-5582-3p	96.3799	NM_030625
TET1	hsa-miR-507	96.273	NM_030625
TET1	hsa-miR-3910	96.1436	NM_030625
TET1	hsa-miR-557	95.9528	NM_030625
TET1	hsa-miR-520f-3p	95.6508	NM_030625
TET1	hsa-miR-3908	94.9713	NM_030625
TET1	hsa-miR-3942-5p	94.594	NM_030625
TET1	hsa-miR-548ar-3p	94.5217	NM_030625
TET1	hsa-miR-4261	94.3556	NM_030625
TET1	hsa-miR-4703-5p	93.9643	NM_030625
TET1	hsa-miR-4770	93.4635	NM_030625
TET1	hsa-miR-143-3p	93.4635	NM_030625
TET1	hsa-miR-190a-3p	93.4099	NM_030625
TET1	hsa-miR-548az-3p	93.0658	NM_030625
TET1	hsa-miR-548e-3p	93.0658	NM_030625
TET1	hsa-miR-548f-3p	93.0658	NM_030625
TET1	hsa-miR-548bc	93.0658	NM_030625
TET1	hsa-miR-6088	93.0214	NM_030625
TET1	hsa-miR-500a-3p	92.9627	NM_030625
TET1	hsa-miR-147b-5p	92.8473	NM_030625
TET1	hsa-miR-8084	92.8313	NM_030625
TET1	hsa-miR-1303	92.7963	NM_030625
TET1	hsa-miR-183-5p	92.6836	NM_030625
TET1	hsa-miR-9851-3p	91.9141	NM_030625
TET1	hsa-miR-450b-5p	91.8912	NM_030625
TET1	hsa-miR-34a-3p	91.7873	NM_030625
TET1	hsa-miR-3065-3p	91.7222	NM_030625
TET1	hsa-miR-106b-5p	91.3005	NM_030625
TET1	hsa-miR-93-5p	91.3005	NM_030625
TET1	hsa-miR-20b-5p	91.3005	NM_030625
TET1	hsa-miR-17-5p	91.3005	NM_030625
TET1	hsa-miR-20a-5p	91.3005	NM_030625
TET1	hsa-miR-519d-3p	91.3005	NM_030625
TET1	hsa-miR-106a-5p	91.3005	NM_030625
TET1	hsa-miR-6768-5p	91.2169	NM_030625
TET1	hsa-miR-205-3p	90.9762	NM_030625
TET1	hsa-miR-548a-3p	90.9587	NM_030625
TET1	hsa-miR-4705	90.8818	NM_030625
TET1	hsa-miR-3140-3p	90.5586	NM_030625
TET1	hsa-miR-5689	90.1991	NM_030625

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Motifs and transcription factors (TFs) regulating TET1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TET1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TET1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TET1	transfac_pro__M07397	ZNF148 (directAnnotation).
TET1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TET1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
TET1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TET1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TET1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TET1	metacluster_7.13	ZFX (directAnnotation).
TET1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TET1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TET1	transfac_pro__M01175	ZBTB7B (directAnnotation).
TET1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TET1	tfdimers__MD00151	CHURC1 (directAnnotation).
TET1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TET1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TET1	transfac_pro__M01303	SP1 (directAnnotation).
TET1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TET1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TET1	transfac_pro__M02090	E2F4 (directAnnotation).
TET1	transfac_pro__M01714	KLF15 (directAnnotation).
TET1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TET1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TET1	transfac_pro__M02089	E2F3 (directAnnotation).
TET1	metacluster_3.14	WT1; WT1 (directAnnotation).
TET1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
TET1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TET1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TET1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TET1	cisbp__M07938	E2F1 (directAnnotation).
TET1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TET1	transfac_pro__M07436	WT1 (directAnnotation).
TET1	transfac_pro__M02281	SP1 (directAnnotation).
TET1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TET1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TET1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
TET1	transfac_pro__M02898	SMAD3 (directAnnotation).
TET1	transfac_public__M00491	PATZ1 (directAnnotation).
TET1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TET1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."