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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TENT5A

Summary for TENT5A

Gene information	Gene symbol	TENT5A
	Ensembl ID	ENSG00000112773
	Entrez ID	55603
	Gene name	terminal nucleotidyltransferase 5A
	Synonyms	C6orf37\|FAM46A\|FLJ20037
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TENT5A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.342645	2.41e-12
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.405086	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.308587	7.36e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.456044	0.00e+00

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Expression of TENT5A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TENT5A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TENT5A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TENT5A	hsa-miR-513b-5p	99.9896	NM_017633
TENT5A	hsa-miR-5011-5p	99.9784	NM_017633
TENT5A	hsa-miR-3163	99.9307	NM_017633
TENT5A	hsa-miR-190a-3p	99.7609	NM_017633
TENT5A	hsa-miR-7-2-3p	99.6419	NM_017633
TENT5A	hsa-miR-7-1-3p	99.6419	NM_017633
TENT5A	hsa-miR-5696	99.568	NM_017633
TENT5A	hsa-miR-8485	99.3612	NM_017633
TENT5A	hsa-miR-410-3p	99.2653	NM_017633
TENT5A	hsa-miR-579-3p	98.2367	NM_017633
TENT5A	hsa-miR-664b-3p	98.2367	NM_017633
TENT5A	hsa-miR-5688	97.5445	NM_017633
TENT5A	hsa-miR-495-3p	96.6254	NM_017633
TENT5A	hsa-miR-1207-3p	96.2411	NM_017633
TENT5A	hsa-miR-1912-5p	95.6689	NM_017633
TENT5A	hsa-miR-6071	95.243	NM_017633
TENT5A	hsa-miR-570-3p	95.0682	NM_017633
TENT5A	hsa-miR-1277-5p	94.5417	NM_017633
TENT5A	hsa-miR-4457	94.2411	NM_017633
TENT5A	hsa-miR-4328	93.9613	NM_017633
TENT5A	hsa-miR-590-3p	93.6482	NM_017633
TENT5A	hsa-miR-9983-3p	93.4006	NM_017633
TENT5A	hsa-miR-6832-3p	92.9912	NM_017633
TENT5A	hsa-miR-6128	92.4748	NM_017633
TENT5A	hsa-miR-6074	92.3395	NM_017633
TENT5A	hsa-miR-1279	91.7323	NM_017633
TENT5A	hsa-miR-5694	91.509	NM_017633
TENT5A	hsa-miR-211-5p	91.4227	NM_017633
TENT5A	hsa-miR-204-5p	91.4227	NM_017633
TENT5A	hsa-miR-6516-5p	91.3229	NM_017633
TENT5A	hsa-miR-3941	91.3206	NM_017633
TENT5A	hsa-miR-125b-2-3p	91.2799	NM_017633
TENT5A	hsa-miR-223-3p	91.1249	NM_017633
TENT5A	hsa-miR-4446-5p	90.6821	NM_017633
TENT5A	hsa-miR-1288-5p	90.5991	NM_017633
TENT5A	hsa-miR-607	90.5674	NM_017633
TENT5A	hsa-miR-101-3p	90.544	NM_017633
TENT5A	hsa-miR-203b-3p	89.4882	NM_017633
TENT5A	hsa-miR-129-5p	88.8902	NM_017633
TENT5A	hsa-miR-7152-5p	88.5771	NM_017633
TENT5A	hsa-miR-4789-3p	88.5583	NM_017633
TENT5A	hsa-miR-133a-3p	88.5418	NM_017633
TENT5A	hsa-miR-133b	88.5418	NM_017633
TENT5A	hsa-miR-5701	88.2395	NM_017633
TENT5A	hsa-miR-3671	88.1271	NM_017633
TENT5A	hsa-miR-451b	87.9245	NM_017633
TENT5A	hsa-miR-10527-5p	87.917	NM_017633
TENT5A	hsa-miR-548c-3p	87.9007	NM_017633
TENT5A	hsa-miR-23c	87.8653	NM_017633
TENT5A	hsa-miR-23b-3p	87.8653	NM_017633

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Motifs and transcription factors (TFs) regulating TENT5A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."