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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TENT4B

Summary for TENT4B

Gene information	Gene symbol	TENT4B
	Ensembl ID	ENSG00000121274
	Entrez ID	64282
	Gene name	terminal nucleotidyltransferase 4B
	Synonyms	PAPD5\|TRF4-2\|TUT3
	Gene type	protein_coding
	UniProtAcc	Q8NDF8

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Dataset with differentially expressed gene: TENT4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.612322	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.499647	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.29668	7.60e-33

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Expression of TENT4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TENT4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TENT4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TENT4B	hsa-miR-5011-5p	99.9599	NM_001040284
TENT4B	hsa-miR-3163	99.6345	NM_001040284
TENT4B	hsa-miR-8485	99.488	NM_001040284
TENT4B	hsa-miR-4262	99.436	NM_001040284
TENT4B	hsa-miR-539-5p	99.415	NM_001040284
TENT4B	hsa-miR-9983-3p	99.269	NM_001040284
TENT4B	hsa-miR-181d-5p	99.2326	NM_001040284
TENT4B	hsa-miR-190a-3p	99.1302	NM_001040284
TENT4B	hsa-miR-12136	99.1084	NM_001040284
TENT4B	hsa-miR-181c-5p	99.0131	NM_001040284
TENT4B	hsa-miR-181a-5p	99.0131	NM_001040284
TENT4B	hsa-miR-181b-5p	99.0131	NM_001040284
TENT4B	hsa-miR-548aw	98.8879	NM_001040284
TENT4B	hsa-miR-129-5p	98.7661	NM_001040284
TENT4B	hsa-miR-4725-5p	98.6653	NM_001040284
TENT4B	hsa-miR-504-5p	98.6653	NM_001040284
TENT4B	hsa-miR-1200	98.5667	NM_001040284
TENT4B	hsa-miR-603	98.4417	NM_001040284
TENT4B	hsa-miR-362-3p	98.1273	NM_001040284
TENT4B	hsa-miR-329-3p	98.1273	NM_001040284
TENT4B	hsa-miR-4251	97.9515	NM_001040284
TENT4B	hsa-miR-4324	97.7507	NM_001040284
TENT4B	hsa-miR-95-5p	97.3079	NM_001040284
TENT4B	hsa-miR-200b-3p	96.8737	NM_001040284
TENT4B	hsa-miR-429	96.8737	NM_001040284
TENT4B	hsa-miR-200c-3p	96.8737	NM_001040284
TENT4B	hsa-miR-4668-5p	96.602	NM_001040284
TENT4B	hsa-miR-216b-3p	96.4658	NM_001040284
TENT4B	hsa-miR-2467-5p	96.3529	NM_001040284
TENT4B	hsa-miR-7159-5p	96.2129	NM_001040284
TENT4B	hsa-miR-4302	95.5008	NM_001040284
TENT4B	hsa-miR-3148	94.8685	NM_001040284
TENT4B	hsa-miR-892c-3p	94.4101	NM_001040284
TENT4B	hsa-miR-6758-5p	93.8632	NM_001040284
TENT4B	hsa-miR-6131	93.8285	NM_001040284
TENT4B	hsa-miR-452-5p	93.7871	NM_001040284
TENT4B	hsa-miR-4676-3p	93.7871	NM_001040284
TENT4B	hsa-miR-383-3p	93.6954	NM_001040284
TENT4B	hsa-miR-141-5p	92.9751	NM_001040284
TENT4B	hsa-miR-6856-5p	92.8202	NM_001040284
TENT4B	hsa-miR-4495	92.7548	NM_001040284
TENT4B	hsa-miR-4276	92.6805	NM_001040284
TENT4B	hsa-miR-3140-3p	92.2944	NM_001040284
TENT4B	hsa-miR-548av-5p	92.1649	NM_001040284
TENT4B	hsa-miR-548k	92.1649	NM_001040284
TENT4B	hsa-miR-8054	92.1649	NM_001040284
TENT4B	hsa-miR-548x-5p	92.1527	NM_001040284
TENT4B	hsa-miR-548g-5p	92.1527	NM_001040284
TENT4B	hsa-miR-548f-5p	92.1527	NM_001040284
TENT4B	hsa-miR-548aj-5p	92.1527	NM_001040284

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Motifs and transcription factors (TFs) regulating TENT4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."