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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TENM4

Summary for TENM4

Gene information	Gene symbol	TENM4
	Ensembl ID	ENSG00000149256
	Entrez ID	26011
	Gene name	teneurin transmembrane protein 4
	Synonyms	DOC4\|KIAA1302\|ODZ4\|Ten-M4\|TEN4
	Gene type	protein_coding
	UniProtAcc	Q6N022

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Dataset with differentially expressed gene: TENM4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.02771	2.63e-04

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Expression of TENM4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TENM4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TENM4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TENM4	hsa-miR-3692-3p	95.2907	NM_001098816
TENM4	hsa-miR-548aw	94.9037	NM_001098816
TENM4	hsa-miR-26b-3p	93.215	NM_001098816
TENM4	hsa-miR-182-5p	92.4369	NM_001098816
TENM4	hsa-miR-6768-5p	90.8842	NM_001098816
TENM4	hsa-miR-6750-5p	90.6558	NM_001098816
TENM4	hsa-miR-6822-5p	90.6558	NM_001098816
TENM4	hsa-miR-544a	90.5362	NM_001098816
TENM4	hsa-miR-4672	89.9566	NM_001098816
TENM4	hsa-miR-153-5p	89.0611	NM_001098816
TENM4	hsa-miR-455-3p	88.982	NM_001098816
TENM4	hsa-miR-4753-5p	88.86	NM_001098816
TENM4	hsa-miR-3925-3p	88.3717	NM_001098816
TENM4	hsa-miR-371b-5p	88.2107	NM_001098816
TENM4	hsa-miR-616-5p	88.2107	NM_001098816
TENM4	hsa-miR-373-5p	88.2107	NM_001098816
TENM4	hsa-miR-4793-3p	87.5177	NM_001098816
TENM4	hsa-miR-924	86.4628	NM_001098816
TENM4	hsa-miR-561-3p	85.8116	NM_001098816
TENM4	hsa-miR-9-5p	85.5666	NM_001098816
TENM4	hsa-miR-3183	85.5458	NM_001098816
TENM4	hsa-miR-887-5p	85.261	NM_001098816
TENM4	hsa-miR-6797-5p	84.8637	NM_001098816
TENM4	hsa-miR-1250-3p	84.5173	NM_001098816
TENM4	hsa-miR-6769b-3p	84.1446	NM_001098816
TENM4	hsa-miR-4723-3p	84.1446	NM_001098816
TENM4	hsa-miR-6830-5p	84.1264	NM_001098816
TENM4	hsa-miR-20a-3p	84.0235	NM_001098816
TENM4	hsa-miR-4267	83.76	NM_001098816
TENM4	hsa-miR-3180-5p	83.7446	NM_001098816
TENM4	hsa-miR-627-3p	83.5115	NM_001098816
TENM4	hsa-miR-1249-5p	83.0698	NM_001098816
TENM4	hsa-miR-6876-3p	82.7067	NM_001098816
TENM4	hsa-miR-626	82.7067	NM_001098816
TENM4	hsa-miR-3926	82.5626	NM_001098816
TENM4	hsa-miR-548az-5p	82.4908	NM_001098816
TENM4	hsa-miR-548t-5p	82.4908	NM_001098816
TENM4	hsa-miR-548c-3p	81.6937	NM_001098816
TENM4	hsa-miR-3119	81.4523	NM_001098816
TENM4	hsa-miR-939-3p	81.3618	NM_001098816
TENM4	hsa-miR-31-5p	80.952	NM_001098816
TENM4	hsa-miR-602	80.264	NM_001098816

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Motifs and transcription factors (TFs) regulating TENM4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TENM4	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
TENM4	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TENM4	transfac_pro__M04617	ZBTB7A (directAnnotation).
TENM4	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TENM4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TENM4	transfac_pro__M07387	ZBTB7A (directAnnotation).
TENM4	transfac_pro__M07436	WT1 (directAnnotation).
TENM4	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TENM4	transfac_pro__M00716	ZBTB14 (directAnnotation).
TENM4	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TENM4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TENM4	transfac_pro__M04893	TAF1 (directAnnotation).
TENM4	transfac_pro__M03876	ZBTB33 (directAnnotation).
TENM4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TENM4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TENM4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."