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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TDG

Summary for TDG

Gene information	Gene symbol	TDG
	Ensembl ID	ENSG00000139372
	Entrez ID	6996
	Gene name	thymine DNA glycosylase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TDG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.322394	3.09e-13
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.429299	7.75e-24
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.34985	4.17e-25
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.773905	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.260439	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.376254	0.00e+00

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Expression of TDG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TDG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TDG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TDG	hsa-miR-3671	99.0211	NM_003211
TDG	hsa-miR-498-3p	97.9682	NM_003211
TDG	hsa-miR-3646	97.9394	NM_003211
TDG	hsa-miR-1184	96.5669	NM_003211
TDG	hsa-miR-548ar-3p	95.5873	NM_003211
TDG	hsa-miR-6875-3p	95.1935	NM_003211
TDG	hsa-miR-6809-3p	95.1252	NM_003211
TDG	hsa-miR-29a-3p	94.936	NM_003211
TDG	hsa-miR-29c-3p	94.936	NM_003211
TDG	hsa-miR-29b-3p	94.936	NM_003211
TDG	hsa-miR-4659a-3p	94.6111	NM_003211
TDG	hsa-miR-4659b-3p	94.6111	NM_003211
TDG	hsa-miR-16-2-3p	93.4961	NM_003211
TDG	hsa-miR-195-3p	93.4961	NM_003211
TDG	hsa-miR-3148	92.8753	NM_003211
TDG	hsa-miR-548bc	92.5821	NM_003211
TDG	hsa-miR-548a-3p	92.5821	NM_003211
TDG	hsa-miR-548e-3p	92.5821	NM_003211
TDG	hsa-miR-548f-3p	92.5821	NM_003211
TDG	hsa-miR-548az-3p	92.5821	NM_003211
TDG	hsa-miR-607	92.496	NM_003211
TDG	hsa-miR-8084	92.4535	NM_003211
TDG	hsa-miR-5696	91.2214	NM_003211
TDG	hsa-miR-103a-3p	91.1288	NM_003211
TDG	hsa-miR-107	91.1288	NM_003211
TDG	hsa-miR-509-3-5p	91.0235	NM_003211
TDG	hsa-miR-509-5p	91.0235	NM_003211
TDG	hsa-miR-4418	90.8688	NM_003211
TDG	hsa-miR-320e	90.227	NM_003211
TDG	hsa-miR-6839-5p	89.9756	NM_003211
TDG	hsa-miR-499b-5p	89.4512	NM_003211
TDG	hsa-miR-30c-5p	89.4411	NM_003211
TDG	hsa-miR-30b-5p	89.4411	NM_003211
TDG	hsa-miR-30d-5p	89.4411	NM_003211
TDG	hsa-miR-30e-5p	89.4411	NM_003211
TDG	hsa-miR-30a-5p	89.4411	NM_003211
TDG	hsa-miR-378j	89.0245	NM_003211
TDG	hsa-miR-331-5p	88.8843	NM_003211
TDG	hsa-miR-6835-3p	87.9414	NM_003211
TDG	hsa-miR-1252-3p	87.1351	NM_003211
TDG	hsa-miR-6886-3p	86.8149	NM_003211
TDG	hsa-miR-454-5p	86.2841	NM_003211
TDG	hsa-miR-549a-3p	85.7435	NM_003211
TDG	hsa-miR-20a-3p	85.6513	NM_003211
TDG	hsa-miR-4319	85.4739	NM_003211
TDG	hsa-miR-217-5p	85.1278	NM_003211
TDG	hsa-miR-340-5p	84.1273	NM_003211
TDG	hsa-miR-548av-3p	83.7988	NM_003211
TDG	hsa-miR-5682	82.6787	NM_003211
TDG	hsa-miR-215-3p	82.1917	NM_003211

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Motifs and transcription factors (TFs) regulating TDG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TDG	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TDG	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TDG	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
TDG	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TDG	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TDG	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TDG	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TDG	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
TDG	hdpi__TP73	TP73 (directAnnotation).
TDG	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
TDG	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
TDG	transfac_pro__M04826	EP300 (directAnnotation).
TDG	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TDG	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TDG	transfac_pro__M04950	EGR1 (directAnnotation).
TDG	transfac_pro__M00652	NRF1 (directAnnotation).
TDG	swissregulon__hs__ETV6	ETV6 (directAnnotation).
TDG	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
TDG	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
TDG	transfac_pro__M05817	ZNF546 (directAnnotation).
TDG	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
TDG	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
TDG	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
TDG	transfac_pro__M06173	ZNF85 (directAnnotation).
TDG	metacluster_81.7	CREB1 (directAnnotation).
TDG	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
TDG	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TDG	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
TDG	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
TDG	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
TDG	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
TDG	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."