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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TCIM

Summary for TCIM

Gene information	Gene symbol	TCIM
	Ensembl ID	ENSG00000176907
	Entrez ID	56892
	Gene name	transcriptional and immune response regulator
	Synonyms	C8orf4\|hTC-1\|TC-1\|TC1
	Gene type	protein_coding
	UniProtAcc	Q9NR00

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Dataset with differentially expressed gene: TCIM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.695614	2.81e-17
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.00143	0.00e+00

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Expression of TCIM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TCIM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TCIM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TCIM	hsa-miR-545-5p	95.9796	NM_020130
TCIM	hsa-miR-4668-5p	93.2375	NM_020130
TCIM	hsa-miR-2052	90.8995	NM_020130
TCIM	hsa-miR-27b-3p	90.4233	NM_020130
TCIM	hsa-miR-27a-3p	90.4233	NM_020130
TCIM	hsa-miR-9985	90.4233	NM_020130
TCIM	hsa-miR-5007-5p	89.907	NM_020130
TCIM	hsa-miR-4795-3p	88.4825	NM_020130
TCIM	hsa-miR-3121-3p	86.9872	NM_020130
TCIM	hsa-miR-6797-3p	86.07	NM_020130
TCIM	hsa-miR-3198	84.5026	NM_020130
TCIM	hsa-miR-4309	84.1833	NM_020130
TCIM	hsa-miR-4294	83.0975	NM_020130
TCIM	hsa-miR-519c-3p	82.9132	NM_020130
TCIM	hsa-miR-519a-3p	82.9132	NM_020130
TCIM	hsa-miR-519b-3p	82.9132	NM_020130
TCIM	hsa-miR-6076	82.1294	NM_020130
TCIM	hsa-miR-19a-3p	82.0705	NM_020130
TCIM	hsa-miR-19b-3p	82.0705	NM_020130
TCIM	hsa-miR-32-3p	81.7454	NM_020130
TCIM	hsa-miR-30a-5p	81.5875	NM_020130
TCIM	hsa-miR-30d-5p	81.5875	NM_020130
TCIM	hsa-miR-30b-5p	81.5875	NM_020130
TCIM	hsa-miR-30e-5p	81.5875	NM_020130
TCIM	hsa-miR-30c-5p	81.5875	NM_020130

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Motifs and transcription factors (TFs) regulating TCIM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."