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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TCF4

Summary for TCF4

Gene information	Gene symbol	TCF4
	Ensembl ID	ENSG00000196628
	Entrez ID	6925
	Gene name	transcription factor 4
	Synonyms	bHLHb19\|E2-2\|ITF2\|SEF2-1B
	Gene type	protein_coding
	UniProtAcc	P15884

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Dataset with differentially expressed gene: TCF4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	1.18131	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.313871	1.23e-39
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.363831	2.73e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	0.571964	1.92e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	0.986621	2.93e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.579665	2.44e-39
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.530388	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.62515	3.22e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.341782	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.263428	2.40e-09

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Expression of TCF4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TCF4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
TCF4	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating TCF4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TCF4	hsa-miR-190a-3p	99.9907	NM_001083962
TCF4	hsa-miR-5011-5p	99.9875	NM_001083962
TCF4	hsa-miR-1283	98.8693	NM_001083962
TCF4	hsa-miR-629-5p	98.7756	NM_001083962
TCF4	hsa-miR-9983-3p	98.4728	NM_001083962
TCF4	hsa-miR-498-3p	97.9006	NM_001083962
TCF4	hsa-miR-129-5p	97.6693	NM_001083962
TCF4	hsa-miR-5688	96.7083	NM_001083962
TCF4	hsa-miR-499b-5p	96.5195	NM_001083962
TCF4	hsa-miR-495-3p	95.7475	NM_001083962
TCF4	hsa-miR-8063	94.2437	NM_001083962
TCF4	hsa-miR-299-3p	93.5566	NM_001083962
TCF4	hsa-miR-4698	93.1554	NM_001083962
TCF4	hsa-miR-4282	92.6936	NM_001083962
TCF4	hsa-miR-520d-5p	92.0689	NM_001083962
TCF4	hsa-miR-524-5p	92.0689	NM_001083962
TCF4	hsa-miR-6793-5p	91.8763	NM_001083962
TCF4	hsa-miR-203a-3p	91.7056	NM_001083962
TCF4	hsa-miR-11181-3p	91.3951	NM_001083962
TCF4	hsa-miR-765	91.3951	NM_001083962
TCF4	hsa-miR-606	91.3303	NM_001083962
TCF4	hsa-miR-1301-3p	91.3105	NM_001083962
TCF4	hsa-miR-5047	91.3105	NM_001083962
TCF4	hsa-miR-3646	89.6047	NM_001083962
TCF4	hsa-miR-493-5p	89.5818	NM_001083962
TCF4	hsa-miR-892c-5p	89.1861	NM_001083962
TCF4	hsa-miR-190b-5p	88.8877	NM_001083962
TCF4	hsa-miR-190a-5p	88.8877	NM_001083962
TCF4	hsa-miR-7851-3p	88.6518	NM_001083962
TCF4	hsa-miR-6716-5p	87.3367	NM_001083962
TCF4	hsa-miR-4477b	87.1852	NM_001083962
TCF4	hsa-miR-200a-3p	86.621	NM_001083962
TCF4	hsa-miR-141-3p	86.621	NM_001083962
TCF4	hsa-miR-1277-5p	86.258	NM_001083962
TCF4	hsa-miR-548f-5p	86.2498	NM_001083962
TCF4	hsa-miR-548aj-5p	86.2498	NM_001083962
TCF4	hsa-miR-548g-5p	86.2498	NM_001083962
TCF4	hsa-miR-548x-5p	86.2498	NM_001083962
TCF4	hsa-miR-4652-3p	86.2047	NM_001083962
TCF4	hsa-miR-5696	85.0503	NM_001083962
TCF4	hsa-miR-4691-3p	84.6981	NM_001083962
TCF4	hsa-miR-335-3p	84.5976	NM_001083962
TCF4	hsa-miR-1468-3p	84.5366	NM_001083962
TCF4	hsa-miR-5583-3p	84.1111	NM_001083962
TCF4	hsa-miR-137-3p	83.9711	NM_001083962
TCF4	hsa-miR-548c-3p	83.7622	NM_001083962
TCF4	hsa-miR-527	83.7601	NM_001083962
TCF4	hsa-miR-518a-5p	83.7601	NM_001083962
TCF4	hsa-miR-335-5p	83.7529	NM_001083962
TCF4	hsa-miR-6839-3p	83.7206	NM_001083962

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Motifs and transcription factors (TFs) regulating TCF4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TCF4	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TCF4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TCF4	transfac_pro__M07397	ZNF148 (directAnnotation).
TCF4	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TCF4	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TCF4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TCF4	metacluster_7.13	ZFX (directAnnotation).
TCF4	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TCF4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TCF4	transfac_pro__M01303	SP1 (directAnnotation).
TCF4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TCF4	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TCF4	transfac_pro__M01714	KLF15 (directAnnotation).
TCF4	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TCF4	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TCF4	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TCF4	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
TCF4	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TCF4	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TCF4	cisbp__M07938	E2F1 (directAnnotation).
TCF4	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
TCF4	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TCF4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TCF4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TCF4	transfac_pro__M02898	SMAD3 (directAnnotation).
TCF4	transfac_public__M00491	PATZ1 (directAnnotation).
TCF4	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
TCF4	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
TCF4	metacluster_141.2	E2F2; E2F3 (directAnnotation).
TCF4	hdpi__TP73	TP73 (directAnnotation).
TCF4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TCF4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TCF4	metacluster_172.6	CHD2; E2F1 (directAnnotation).
TCF4	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
TCF4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TCF4	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
TCF4	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
TCF4	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
TCF4	hdpi__FLI1	FLI1 (directAnnotation).
TCF4	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
TCF4	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
TCF4	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
TCF4	jaspar__MA1935.1	FOXI1 (directAnnotation).
TCF4	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
TCF4	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TCF4	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
TCF4	transfac_pro__M00492	STAT1 (directAnnotation).
TCF4	swissregulon__hs__ETV6	ETV6 (directAnnotation).
TCF4	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
TCF4	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."