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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TCEA1

Summary for TCEA1

Gene information	Gene symbol	TCEA1
	Ensembl ID	ENSG00000187735
	Entrez ID	6917
	Gene name	transcription elongation factor A1
	Synonyms	GTF2S\|SII\|TCEA\|TF2S\|TFIIS
	Gene type	protein_coding
	UniProtAcc	P23193

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Dataset with differentially expressed gene: TCEA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.905609	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.298116	7.56e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.677725	3.36e-31
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.352354	5.84e-15
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.265557	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.263912	2.43e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.608217	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.321975	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.305158	1.12e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.393982	2.97e-30
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.327654	4.35e-16
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.620008	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.495554	0.00e+00

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Expression of TCEA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TCEA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TCEA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TCEA1	hsa-miR-3529-3p	98.0359	NM_201437
TCEA1	hsa-miR-3065-5p	97.8949	NM_201437
TCEA1	hsa-miR-8063	97.3668	NM_006756
TCEA1	hsa-miR-9-3p	96.5326	NM_006756
TCEA1	hsa-miR-192-3p	95.7752	NM_201437
TCEA1	hsa-miR-3688-3p	95.5062	NM_201437
TCEA1	hsa-miR-4307	94.5922	NM_201437
TCEA1	hsa-miR-196a-1-3p	93.5156	NM_201437
TCEA1	hsa-miR-3658	92.1101	NM_201437
TCEA1	hsa-miR-548t-5p	91.7943	NM_201437
TCEA1	hsa-miR-548az-5p	91.7943	NM_201437
TCEA1	hsa-miR-3148	91.7618	NM_201437
TCEA1	hsa-miR-4698	90.769	NM_006756
TCEA1	hsa-miR-548at-5p	89.6594	NM_006756
TCEA1	hsa-miR-12136	89.0356	NM_006756
TCEA1	hsa-miR-3651	88.7047	NM_201437
TCEA1	hsa-miR-198	88.4244	NM_006756
TCEA1	hsa-miR-340-5p	88.3459	NM_006756
TCEA1	hsa-miR-488-5p	85.8764	NM_201437
TCEA1	hsa-miR-320e	85.8024	NM_201437
TCEA1	hsa-miR-3145-5p	85.6031	NM_201437
TCEA1	hsa-miR-567	85.3091	NM_006756
TCEA1	hsa-miR-500a-5p	84.7157	NM_201437
TCEA1	hsa-miR-3681-3p	84.4319	NM_201437
TCEA1	hsa-miR-216a-3p	84.4314	NM_201437
TCEA1	hsa-miR-128-3p	84.4314	NM_201437
TCEA1	hsa-miR-494-3p	83.4657	NM_006756
TCEA1	hsa-miR-4668-5p	83.1913	NM_201437
TCEA1	hsa-miR-4695-3p	82.9775	NM_201437
TCEA1	hsa-miR-362-3p	82.905	NM_201437
TCEA1	hsa-miR-329-3p	82.905	NM_201437
TCEA1	hsa-miR-3163	82.8254	NM_006756
TCEA1	hsa-miR-1468-3p	82.5318	NM_201437
TCEA1	hsa-miR-520d-5p	81.661	NM_201437
TCEA1	hsa-miR-524-5p	81.661	NM_201437
TCEA1	hsa-miR-5683	81.4579	NM_006756
TCEA1	hsa-miR-8076	80.928	NM_201437
TCEA1	hsa-miR-4279	80.4054	NM_201437

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Motifs and transcription factors (TFs) regulating TCEA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TCEA1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
TCEA1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
TCEA1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
TCEA1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
TCEA1	metacluster_35.7	HINFP (inferredBy_Orthology).
TCEA1	metacluster_98.1	ZNF524 (directAnnotation).
TCEA1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TCEA1	transfac_pro__M00652	NRF1 (directAnnotation).
TCEA1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
TCEA1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TCEA1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
TCEA1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TCEA1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
TCEA1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TCEA1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
TCEA1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TCEA1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
TCEA1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TCEA1	jaspar__MA1122.1	TFDP1 (directAnnotation).
TCEA1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TCEA1	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
TCEA1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TCEA1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
TCEA1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TCEA1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
TCEA1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
TCEA1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
TCEA1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TCEA1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TCEA1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
TCEA1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TCEA1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TCEA1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TCEA1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TCEA1	metacluster_35.10	ZNF681; ZNF681 (directAnnotation).
TCEA1	jaspar__MA1522.1	MAZ (directAnnotation).
TCEA1	swissregulon__hs__RUNX2	RUNX2 (directAnnotation).
TCEA1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TCEA1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
TCEA1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TCEA1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TCEA1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."