Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TCAIM

Summary for TCAIM

Gene information	Gene symbol	TCAIM
	Ensembl ID	ENSG00000179152
	Entrez ID	285343
	Gene name	T cell activation inhibitor, mitochondrial
	Synonyms	C3orf23\|DKFZp313N0621\|TOAG-1
	Gene type	protein_coding
	UniProtAcc	Q8N3R3

Top

Dataset with differentially expressed gene: TCAIM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.88152	6.68e-06

Top

Expression of TCAIM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TCAIM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TCAIM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TCAIM	hsa-miR-3163	97.7587	NM_001282913
TCAIM	hsa-miR-335-3p	96.4612	NM_001029839
TCAIM	hsa-miR-4677-5p	93.9554	NM_001282913
TCAIM	hsa-miR-569	93.6477	NM_001029839
TCAIM	hsa-miR-4775	92.7342	NM_001282913
TCAIM	hsa-miR-4714-5p	92.1947	NM_001282913
TCAIM	hsa-miR-4795-3p	91.6626	NM_001282913
TCAIM	hsa-miR-8068	91.3148	NM_001029839
TCAIM	hsa-miR-6739-3p	91.1737	NM_001282913
TCAIM	hsa-miR-5094	91.0273	NM_001029839
TCAIM	hsa-miR-548as-3p	90.9818	NM_001029839
TCAIM	hsa-miR-4752	90.1988	NM_001282913
TCAIM	hsa-miR-429	89.7096	NM_001282913
TCAIM	hsa-miR-200c-3p	89.7096	NM_001282913
TCAIM	hsa-miR-200b-3p	89.7096	NM_001282913
TCAIM	hsa-miR-4495	89.6657	NM_001282913
TCAIM	hsa-miR-4791	89.2458	NM_001029839
TCAIM	hsa-miR-10527-5p	88.9682	NM_001029839
TCAIM	hsa-miR-4251	88.5395	NM_001282913
TCAIM	hsa-miR-195-5p	88.4	NM_001282913
TCAIM	hsa-miR-15a-5p	88.0994	NM_001282913
TCAIM	hsa-miR-16-5p	88.0994	NM_001282913
TCAIM	hsa-miR-497-5p	88.0994	NM_001282913
TCAIM	hsa-miR-424-5p	88.0994	NM_001282913
TCAIM	hsa-miR-15b-5p	88.0994	NM_001282913
TCAIM	hsa-miR-6838-5p	88.0994	NM_001282913
TCAIM	hsa-miR-548c-3p	87.6257	NM_001282913
TCAIM	hsa-miR-6508-5p	87.4006	NM_001282913
TCAIM	hsa-miR-302e	87.3504	NM_001029839
TCAIM	hsa-miR-6895-3p	86.2748	NM_001029839
TCAIM	hsa-miR-3529-3p	86.2723	NM_001029839
TCAIM	hsa-miR-5692b	86.2414	NM_001029839
TCAIM	hsa-miR-5692c	86.2414	NM_001029839
TCAIM	hsa-miR-5692a	86.1276	NM_001282913
TCAIM	hsa-miR-8057	85.9651	NM_001282913
TCAIM	hsa-miR-8067	85.1961	NM_001282913
TCAIM	hsa-miR-411-3p	85.0504	NM_001282913
TCAIM	hsa-miR-379-3p	85.0504	NM_001282913
TCAIM	hsa-miR-3201	84.61	NM_001029839
TCAIM	hsa-miR-374a-5p	84.5955	NM_001282913
TCAIM	hsa-miR-302b-3p	82.6385	NM_001029839
TCAIM	hsa-miR-302c-3p	82.6385	NM_001029839
TCAIM	hsa-miR-302d-3p	82.6385	NM_001029839
TCAIM	hsa-miR-302a-3p	82.6385	NM_001029839
TCAIM	hsa-miR-34c-3p	82.1619	NM_001282913
TCAIM	hsa-miR-34a-3p	81.6892	NM_001029839
TCAIM	hsa-miR-374b-5p	81.5831	NM_001282913
TCAIM	hsa-miR-7844-5p	81.5506	NM_001029839
TCAIM	hsa-miR-584-5p	81.0272	NM_001029839
TCAIM	hsa-miR-12128	80.8787	NM_001029839

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating TCAIM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TCAIM	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
TCAIM	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TCAIM	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TCAIM	transfac_pro__M04617	ZBTB7A (directAnnotation).
TCAIM	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TCAIM	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
TCAIM	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TCAIM	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TCAIM	transfac_pro__M07387	ZBTB7A (directAnnotation).
TCAIM	transfac_pro__M07436	WT1 (directAnnotation).
TCAIM	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TCAIM	transfac_pro__M00716	ZBTB14 (directAnnotation).
TCAIM	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TCAIM	hdpi__HIP2	UBE2K (directAnnotation).
TCAIM	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TCAIM	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TCAIM	transfac_pro__M04893	TAF1 (directAnnotation).
TCAIM	transfac_pro__M03876	ZBTB33 (directAnnotation).
TCAIM	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TCAIM	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TCAIM	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
TCAIM	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TCAIM	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."