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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TCAF1

Summary for TCAF1

Gene information	Gene symbol	TCAF1
	Ensembl ID	ENSG00000198420
	Entrez ID	9747
	Gene name	TRPM8 channel associated factor 1
	Synonyms	FAM115A\|GATD9A\|KIAA0738
	Gene type	protein_coding
	UniProtAcc	Q9Y4C2

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Dataset with differentially expressed gene: TCAF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.359723	0.00e+00

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Expression of TCAF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TCAF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TCAF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TCAF1	hsa-miR-6839-3p	95.7463	NM_001206941
TCAF1	hsa-miR-629-5p	89.5038	NM_001206941
TCAF1	hsa-miR-141-5p	87.0358	NM_001206941
TCAF1	hsa-miR-3059-5p	86.8531	NM_001206941
TCAF1	hsa-miR-6855-5p	85.0152	NM_001206938
TCAF1	hsa-miR-4328	84.0187	NM_001206941
TCAF1	hsa-miR-584-3p	83.2025	NM_001206941
TCAF1	hsa-miR-4427	82.5576	NM_001206941
TCAF1	hsa-let-7g-3p	82.3138	NM_001206941
TCAF1	hsa-let-7a-2-3p	82.3138	NM_001206941
TCAF1	hsa-miR-3170	82.1671	NM_001206938
TCAF1	hsa-miR-9902	81.3073	NM_001206941
TCAF1	hsa-miR-1236-3p	80.3797	NM_001206941
TCAF1	hsa-miR-3973	80.1041	NM_001206941

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Motifs and transcription factors (TFs) regulating TCAF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TCAF1	transfac_pro__M06135	ZNF28 (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."