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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBX3

Summary for TBX3

Gene information	Gene symbol	TBX3
	Ensembl ID	ENSG00000135111
	Entrez ID	6926
	Gene name	T-box transcription factor 3
	Synonyms	TBX3-ISO\|UMS\|XHL
	Gene type	protein_coding
	UniProtAcc	O15119

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Dataset with differentially expressed gene: TBX3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-2.04674	2.68e-05
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.44055	1.88e-22
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.550611	1.10e-08
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.295784	1.82e-31
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.407965	0.00e+00

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Expression of TBX3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBX3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBX3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBX3	hsa-miR-95-5p	99.1924	NM_005996
TBX3	hsa-miR-561-3p	97.33	NM_005996
TBX3	hsa-miR-448	95.9257	NM_005996
TBX3	hsa-miR-6873-3p	95.8787	NM_005996
TBX3	hsa-miR-3661	93.8414	NM_005996
TBX3	hsa-miR-631	93.4579	NM_005996
TBX3	hsa-miR-4515	92.1895	NM_005996
TBX3	hsa-miR-7850-5p	90.0377	NM_005996
TBX3	hsa-miR-7154-5p	89.6073	NM_005996
TBX3	hsa-miR-7856-5p	89.3967	NM_005996
TBX3	hsa-miR-548d-3p	88.8004	NM_005996
TBX3	hsa-miR-548z	88.8004	NM_005996
TBX3	hsa-miR-548bb-3p	88.8004	NM_005996
TBX3	hsa-miR-548ac	88.8004	NM_005996
TBX3	hsa-miR-548h-3p	88.8004	NM_005996
TBX3	hsa-miR-497-3p	88.7791	NM_005996
TBX3	hsa-miR-4477b	87.9774	NM_005996
TBX3	hsa-miR-4795-3p	87.0031	NM_005996
TBX3	hsa-miR-499b-3p	86.7375	NM_005996
TBX3	hsa-miR-499a-3p	86.7375	NM_005996
TBX3	hsa-miR-5011-5p	86.5035	NM_005996
TBX3	hsa-miR-4520-2-3p	86.4503	NM_005996
TBX3	hsa-miR-4276	85.5697	NM_005996
TBX3	hsa-miR-4760-3p	85.466	NM_005996
TBX3	hsa-miR-570-3p	85.2285	NM_005996
TBX3	hsa-miR-206	84.6312	NM_005996
TBX3	hsa-miR-1-3p	84.6312	NM_005996
TBX3	hsa-miR-1252-5p	84.423	NM_005996
TBX3	hsa-miR-3129-5p	81.5956	NM_005996
TBX3	hsa-miR-199a-3p	81.5956	NM_005996
TBX3	hsa-miR-199b-3p	81.5956	NM_005996
TBX3	hsa-miR-513b-5p	81.5073	NM_005996
TBX3	hsa-miR-548ap-3p	81.3595	NM_005996
TBX3	hsa-miR-548t-3p	81.3595	NM_005996
TBX3	hsa-miR-548aa	81.3595	NM_005996
TBX3	hsa-miR-205-5p	81.1335	NM_005996
TBX3	hsa-miR-613	81.0645	NM_005996
TBX3	hsa-miR-3616-3p	81.0323	NM_005996

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Motifs and transcription factors (TFs) regulating TBX3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBX3	hdpi__NFIX	NFIX (directAnnotation).
TBX3	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
TBX3	hdpi__ZNF193	ZSCAN9 (directAnnotation).
TBX3	hdpi__FOXM1	FOXM1 (directAnnotation).
TBX3	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
TBX3	tfdimers__MD00292	HLTF; POU5F1 (directAnnotation).
TBX3	metacluster_84.16	RARB (directAnnotation).
TBX3	tfdimers__MD00527	IRF1; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; ZEB1 (directAnnotation).
TBX3	tfdimers__MD00361	FOXA1; FOXA2; FOXA3; GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
TBX3	transfac_pro__M06952	BATF (directAnnotation).
TBX3	metacluster_131.3	ZNF436 (inferredBy_Orthology).
TBX3	transfac_pro__M06959	ZNF425 (directAnnotation).
TBX3	transfac_pro__M06353	ZNF782 (directAnnotation).
TBX3	swissregulon__hs__ZNF691	ZNF691 (directAnnotation).
TBX3	transfac_pro__M06357	ZNF629 (inferredBy_Orthology).
TBX3	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
TBX3	swissregulon__hs__DBP	DBP (directAnnotation).
TBX3	transfac_pro__M07607	NFATC3 (directAnnotation).
TBX3	transfac_pro__M12556	ETV4 (directAnnotation).
TBX3	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
TBX3	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."