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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBPL1

Summary for TBPL1

Gene information	Gene symbol	TBPL1
	Ensembl ID	ENSG00000028839
	Entrez ID	9519
	Gene name	TATA-box binding protein like 1
	Synonyms	STUD\|TLF\|TLP\|TRF2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TBPL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.372874	8.11e-33
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.376899	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.257167	8.89e-25

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Expression of TBPL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBPL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBPL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBPL1	hsa-miR-3907	96.7117	NM_001253676
TBPL1	hsa-miR-15b-5p	95.7413	NM_001253676
TBPL1	hsa-miR-424-5p	95.7413	NM_001253676
TBPL1	hsa-miR-195-5p	95.7121	NM_001253676
TBPL1	hsa-miR-497-5p	95.7121	NM_001253676
TBPL1	hsa-miR-6838-5p	95.7121	NM_001253676
TBPL1	hsa-miR-16-5p	95.7121	NM_001253676
TBPL1	hsa-miR-15a-5p	95.7121	NM_001253676
TBPL1	hsa-miR-6504-3p	95.3578	NM_001253676
TBPL1	hsa-miR-10399-5p	95.3578	NM_001253676
TBPL1	hsa-miR-3944-5p	94.9679	NM_001253676
TBPL1	hsa-miR-5689	94.3686	NM_001253676
TBPL1	hsa-miR-3148	93.7506	NM_001253676
TBPL1	hsa-miR-3085-5p	93.1809	NM_001253676
TBPL1	hsa-miR-4668-3p	92.71	NM_001253676
TBPL1	hsa-miR-670-3p	92.109	NM_001253676
TBPL1	hsa-miR-2113	91.0404	NM_001253676
TBPL1	hsa-miR-9-5p	90.995	NM_001253676
TBPL1	hsa-miR-4719	89.6184	NM_001253676
TBPL1	hsa-miR-4694-3p	88.4877	NM_001253676
TBPL1	hsa-miR-3121-3p	87.8401	NM_001253676
TBPL1	hsa-miR-8081	86.7094	NM_001253676
TBPL1	hsa-miR-3120-3p	86.5078	NM_001253676
TBPL1	hsa-miR-133b	86.0761	NM_001253676
TBPL1	hsa-miR-133a-3p	86.0761	NM_001253676
TBPL1	hsa-miR-4262	85.7872	NM_001253676
TBPL1	hsa-miR-4291	84.2626	NM_001253676
TBPL1	hsa-miR-6505-5p	83.9074	NM_001253676
TBPL1	hsa-miR-181d-5p	83.8361	NM_001253676
TBPL1	hsa-miR-181c-5p	83.8361	NM_001253676
TBPL1	hsa-miR-181a-5p	83.8361	NM_001253676
TBPL1	hsa-miR-181b-5p	83.8361	NM_001253676
TBPL1	hsa-miR-4735-3p	82.397	NM_001253676
TBPL1	hsa-miR-548e-5p	81.1423	NM_001253676
TBPL1	hsa-miR-506-5p	80.8413	NM_001253676
TBPL1	hsa-miR-892c-5p	80.8413	NM_001253676
TBPL1	hsa-miR-7161-5p	80.3043	NM_001253676
TBPL1	hsa-miR-548u	80.3043	NM_001253676

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Motifs and transcription factors (TFs) regulating TBPL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBPL1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
TBPL1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
TBPL1	transfac_pro__M06035	ZNF749 (directAnnotation).
TBPL1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
TBPL1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
TBPL1	metacluster_52.11	ZNF184 (directAnnotation).
TBPL1	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
TBPL1	metacluster_98.1	ZNF524 (directAnnotation).
TBPL1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
TBPL1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TBPL1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TBPL1	jaspar__MA1483.2	ELF2 (directAnnotation).
TBPL1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TBPL1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TBPL1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
TBPL1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
TBPL1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
TBPL1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
TBPL1	jaspar__MA1933.1	SREBF2 (directAnnotation).
TBPL1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
TBPL1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
TBPL1	cisbp__M02645	ETS1 (directAnnotation).
TBPL1	jaspar__MA1708.1	ETV7 (directAnnotation).
TBPL1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
TBPL1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
TBPL1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TBPL1	hdpi__ETV4	ETV4 (directAnnotation).
TBPL1	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
TBPL1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
TBPL1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
TBPL1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
TBPL1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
TBPL1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
TBPL1	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
TBPL1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TBPL1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TBPL1	metacluster_7.13	ZFX (directAnnotation).
TBPL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TBPL1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
TBPL1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TBPL1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TBPL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TBPL1	cisbp__M00249	WT1 (directAnnotation).
TBPL1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TBPL1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TBPL1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TBPL1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TBPL1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TBPL1	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."