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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBCEL

Summary for TBCEL

Gene information	Gene symbol	TBCEL
	Ensembl ID	ENSG00000154114
	Entrez ID	219899
	Gene name	tubulin folding cofactor E like
	Synonyms	LRRC35\|MGC10233
	Gene type	protein_coding
	UniProtAcc	Q5QJ74

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Dataset with differentially expressed gene: TBCEL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.707015	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.397313	0.00e+00

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Expression of TBCEL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBCEL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBCEL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBCEL	hsa-miR-3163	96.9733	NM_001130047
TBCEL	hsa-miR-5692a	96.8913	NM_001130047
TBCEL	hsa-miR-548c-3p	96.8623	NM_001130047
TBCEL	hsa-miR-589-3p	95.7604	NM_152715
TBCEL	hsa-miR-497-3p	95.4369	NM_001130047
TBCEL	hsa-miR-548aa	95.4251	NM_001130047
TBCEL	hsa-miR-548t-3p	95.4251	NM_001130047
TBCEL	hsa-miR-548ap-3p	95.4251	NM_001130047
TBCEL	hsa-miR-3646	95.2435	NM_152715
TBCEL	hsa-miR-944	95.1152	NM_152715
TBCEL	hsa-miR-6882-5p	94.575	NM_152715
TBCEL	hsa-miR-4324	93.8691	NM_001130047
TBCEL	hsa-miR-4436b-5p	93.6319	NM_152715
TBCEL	hsa-miR-4776-3p	93.5978	NM_152715
TBCEL	hsa-miR-6874-3p	92.7542	NM_152715
TBCEL	hsa-miR-148b-5p	92.7542	NM_152715
TBCEL	hsa-miR-548t-5p	91.4989	NM_152715
TBCEL	hsa-miR-548az-5p	91.4989	NM_152715
TBCEL	hsa-miR-548aw	90.9651	NM_001130047
TBCEL	hsa-miR-3613-3p	90.1796	NM_152715
TBCEL	hsa-miR-3173-5p	90.0972	NM_001130047
TBCEL	hsa-miR-6799-3p	90.0972	NM_001130047
TBCEL	hsa-miR-6719-3p	89.7828	NM_152715
TBCEL	hsa-miR-1323	89.7192	NM_152715
TBCEL	hsa-miR-548o-3p	89.7192	NM_152715
TBCEL	hsa-miR-1468-3p	89.0986	NM_152715
TBCEL	hsa-miR-3065-3p	88.405	NM_152715
TBCEL	hsa-miR-6809-3p	88.1671	NM_152715
TBCEL	hsa-miR-625-5p	88.1274	NM_152715
TBCEL	hsa-miR-6760-5p	87.9041	NM_152715
TBCEL	hsa-miR-4262	87.689	NM_152715
TBCEL	hsa-miR-6833-3p	87.5925	NM_152715
TBCEL	hsa-miR-1184	87.1978	NM_152715
TBCEL	hsa-miR-4668-5p	87.1553	NM_152715
TBCEL	hsa-miR-4768-5p	84.8324	NM_152715
TBCEL	hsa-miR-6878-5p	84.4488	NM_152715
TBCEL	hsa-miR-6757-3p	83.9828	NM_152715
TBCEL	hsa-miR-650	83.8255	NM_152715
TBCEL	hsa-miR-3612	83.8255	NM_152715
TBCEL	hsa-miR-181b-5p	83.6765	NM_152715
TBCEL	hsa-miR-181a-5p	83.6765	NM_152715
TBCEL	hsa-miR-181d-5p	83.6765	NM_152715
TBCEL	hsa-miR-181c-5p	83.6765	NM_152715
TBCEL	hsa-miR-4422	83.1426	NM_152715
TBCEL	hsa-miR-513b-5p	82.9189	NM_152715
TBCEL	hsa-miR-4275	82.5987	NM_152715
TBCEL	hsa-miR-153-5p	82.5785	NM_152715
TBCEL	hsa-miR-539-5p	81.5113	NM_152715
TBCEL	hsa-miR-4667-3p	81.4793	NM_152715
TBCEL	hsa-miR-4650-3p	80.984	NM_001130047

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Motifs and transcription factors (TFs) regulating TBCEL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBCEL	transfac_pro__M06554	ZNF483 (directAnnotation).
TBCEL	metacluster_141.4	GLIS2 (directAnnotation).
TBCEL	cisbp__M08198	ELF1 (directAnnotation).
TBCEL	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
TBCEL	transfac_pro__M01968	FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."