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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBC1D5

Summary for TBC1D5

Gene information	Gene symbol	TBC1D5
	Ensembl ID	ENSG00000131374
	Entrez ID	9779
	Gene name	TBC1 domain family member 5
	Synonyms	KIAA0210
	Gene type	protein_coding
	UniProtAcc	Q92609

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Dataset with differentially expressed gene: TBC1D5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.015	1.35e-05

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Expression of TBC1D5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBC1D5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBC1D5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBC1D5	hsa-miR-4306	94.4452	NM_014744
TBC1D5	hsa-miR-3120-5p	93.2555	NM_001134381
TBC1D5	hsa-miR-4644	91.9725	NM_014744
TBC1D5	hsa-miR-185-5p	91.9725	NM_014744
TBC1D5	hsa-miR-301b-5p	91.9302	NM_001134381
TBC1D5	hsa-miR-506-5p	91.0504	NM_001134381
TBC1D5	hsa-miR-4428	90.4044	NM_001134381
TBC1D5	hsa-miR-301a-5p	89.6538	NM_001134381
TBC1D5	hsa-miR-6886-5p	88.6097	NM_001134381
TBC1D5	hsa-miR-1255a	86.3699	NM_001134381
TBC1D5	hsa-miR-1255b-5p	86.3699	NM_001134381
TBC1D5	hsa-miR-7108-5p	85.0625	NM_001134381
TBC1D5	hsa-miR-1227-5p	84.896	NM_001134381
TBC1D5	hsa-miR-3144-5p	84.287	NM_001134381
TBC1D5	hsa-miR-4252	83.7572	NM_001134381
TBC1D5	hsa-miR-6509-3p	83.7106	NM_001134381
TBC1D5	hsa-miR-17-3p	83.6526	NM_001134381
TBC1D5	hsa-miR-3163	82.9543	NM_001134381
TBC1D5	hsa-miR-4492	82.4839	NM_014744
TBC1D5	hsa-miR-3922-3p	82.375	NM_001134381
TBC1D5	hsa-miR-539-5p	81.8695	NM_001134381
TBC1D5	hsa-miR-181a-2-3p	81.8298	NM_001134381
TBC1D5	hsa-miR-146a-3p	81.7279	NM_001134381
TBC1D5	hsa-miR-4653-5p	80.7646	NM_001134381
TBC1D5	hsa-miR-1228-3p	80.2774	NM_001134381

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Motifs and transcription factors (TFs) regulating TBC1D5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBC1D5	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
TBC1D5	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TBC1D5	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TBC1D5	transfac_pro__M04617	ZBTB7A (directAnnotation).
TBC1D5	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TBC1D5	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TBC1D5	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TBC1D5	transfac_pro__M07387	ZBTB7A (directAnnotation).
TBC1D5	transfac_pro__M07436	WT1 (directAnnotation).
TBC1D5	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TBC1D5	transfac_pro__M00716	ZBTB14 (directAnnotation).
TBC1D5	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TBC1D5	hdpi__HIP2	UBE2K (directAnnotation).
TBC1D5	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TBC1D5	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TBC1D5	transfac_pro__M04893	TAF1 (directAnnotation).
TBC1D5	transfac_pro__M03876	ZBTB33 (directAnnotation).
TBC1D5	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TBC1D5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TBC1D5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TBC1D5	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."