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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBC1D30

Summary for TBC1D30

Gene information	Gene symbol	TBC1D30
	Ensembl ID	ENSG00000111490
	Entrez ID	23329
	Gene name	TBC1 domain family member 30
	Synonyms	KIAA0984
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TBC1D30

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.444476	0.00e+00

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Expression of TBC1D30 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBC1D30

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBC1D30

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBC1D30	hsa-miR-421	98.1911	NM_015279
TBC1D30	hsa-miR-6507-5p	93.6677	NM_015279
TBC1D30	hsa-miR-7110-5p	92.06	NM_015279
TBC1D30	hsa-miR-6842-5p	92.06	NM_015279
TBC1D30	hsa-miR-1297	91.9509	NM_015279
TBC1D30	hsa-miR-6751-5p	91.3335	NM_015279
TBC1D30	hsa-miR-4306	90.995	NM_015279
TBC1D30	hsa-miR-548c-3p	90.4775	NM_015279
TBC1D30	hsa-miR-6752-5p	90.0069	NM_015279
TBC1D30	hsa-miR-6803-5p	88.8518	NM_015279
TBC1D30	hsa-miR-708-3p	88.6098	NM_015279
TBC1D30	hsa-miR-651-3p	88.4902	NM_015279
TBC1D30	hsa-miR-7159-5p	88.371	NM_015279
TBC1D30	hsa-miR-6800-3p	87.8582	NM_015279
TBC1D30	hsa-miR-4644	86.8124	NM_015279
TBC1D30	hsa-miR-185-5p	86.8124	NM_015279
TBC1D30	hsa-miR-323b-3p	84.3443	NM_015279
TBC1D30	hsa-miR-3202	83.9775	NM_015279
TBC1D30	hsa-miR-661	83.9381	NM_015279
TBC1D30	hsa-miR-26a-5p	83.8426	NM_015279
TBC1D30	hsa-miR-26b-5p	83.8426	NM_015279
TBC1D30	hsa-miR-1914-5p	82.4633	NM_015279
TBC1D30	hsa-miR-1279	82.4296	NM_015279

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Motifs and transcription factors (TFs) regulating TBC1D30

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBC1D30	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TBC1D30	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TBC1D30	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TBC1D30	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."