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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBC1D2B

Summary for TBC1D2B

Gene information	Gene symbol	TBC1D2B
	Ensembl ID	ENSG00000167202
	Entrez ID	23102
	Gene name	TBC1 domain family member 2B
	Synonyms	KIAA1055
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TBC1D2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.263639	3.76e-18

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Expression of TBC1D2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBC1D2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBC1D2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBC1D2B	hsa-miR-3163	98.3115	NM_015079
TBC1D2B	hsa-miR-7155-5p	93.4382	NM_015079
TBC1D2B	hsa-miR-6508-5p	93.4367	NM_144572
TBC1D2B	hsa-miR-98-3p	92.5192	NM_144572
TBC1D2B	hsa-let-7f-1-3p	92.5192	NM_144572
TBC1D2B	hsa-let-7a-3p	92.5192	NM_144572
TBC1D2B	hsa-let-7b-3p	92.5192	NM_144572
TBC1D2B	hsa-miR-6875-3p	91.8694	NM_144572
TBC1D2B	hsa-miR-4673	91.5259	NM_144572
TBC1D2B	hsa-miR-8067	88.9737	NM_144572
TBC1D2B	hsa-miR-4794	88.6717	NM_144572
TBC1D2B	hsa-miR-194-3p	87.0037	NM_144572
TBC1D2B	hsa-miR-4645-5p	86.8821	NM_144572
TBC1D2B	hsa-miR-6073	86.1086	NM_015079
TBC1D2B	hsa-miR-664a-5p	85.705	NM_144572
TBC1D2B	hsa-miR-3121-3p	85.6703	NM_015079
TBC1D2B	hsa-miR-3689a-5p	85.3078	NM_144572
TBC1D2B	hsa-miR-3689f	85.3078	NM_144572
TBC1D2B	hsa-miR-3689e	85.3078	NM_144572
TBC1D2B	hsa-miR-3689b-5p	85.3078	NM_144572
TBC1D2B	hsa-miR-5193	84.7997	NM_015079
TBC1D2B	hsa-miR-4514	84.6506	NM_144572
TBC1D2B	hsa-miR-4692	84.6506	NM_144572
TBC1D2B	hsa-miR-3918	84.2031	NM_015079
TBC1D2B	hsa-miR-4267	83.5213	NM_015079
TBC1D2B	hsa-miR-545-3p	83.4417	NM_144572
TBC1D2B	hsa-miR-564	83.3268	NM_144572
TBC1D2B	hsa-miR-4261	83.2872	NM_144572
TBC1D2B	hsa-miR-30c-5p	82.5661	NM_015079
TBC1D2B	hsa-miR-30d-5p	82.5661	NM_015079
TBC1D2B	hsa-miR-30b-5p	82.5661	NM_015079
TBC1D2B	hsa-miR-30a-5p	82.5661	NM_015079
TBC1D2B	hsa-miR-30e-5p	82.5661	NM_015079
TBC1D2B	hsa-miR-8485	82.56	NM_144572
TBC1D2B	hsa-miR-147b-5p	81.4959	NM_144572
TBC1D2B	hsa-miR-6504-5p	80.2926	NM_144572
TBC1D2B	hsa-miR-149-5p	80.2926	NM_144572
TBC1D2B	hsa-miR-3064-5p	80.2926	NM_144572
TBC1D2B	hsa-miR-3085-3p	80.2926	NM_144572

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Motifs and transcription factors (TFs) regulating TBC1D2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBC1D2B	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."