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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBC1D23

Summary for TBC1D23

Gene information	Gene symbol	TBC1D23
	Ensembl ID	ENSG00000036054
	Entrez ID	55773
	Gene name	TBC1 domain family member 23
	Synonyms	FLJ11046
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TBC1D23

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.379758	3.06e-42

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Expression of TBC1D23 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBC1D23

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBC1D23

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBC1D23	hsa-miR-548aa	99.6534	NM_001199198
TBC1D23	hsa-miR-548t-3p	99.6534	NM_001199198
TBC1D23	hsa-miR-548ap-3p	99.6534	NM_001199198
TBC1D23	hsa-miR-30d-3p	98.9623	NM_001199198
TBC1D23	hsa-miR-30a-3p	98.9623	NM_001199198
TBC1D23	hsa-miR-30e-3p	98.9623	NM_001199198
TBC1D23	hsa-miR-676-5p	98.4853	NM_018309
TBC1D23	hsa-miR-3658	98.0749	NM_018309
TBC1D23	hsa-miR-374a-5p	97.1964	NM_018309
TBC1D23	hsa-miR-374b-5p	95.3237	NM_018309
TBC1D23	hsa-miR-7849-3p	95.0676	NM_018309
TBC1D23	hsa-miR-6515-3p	94.9646	NM_001199198
TBC1D23	hsa-miR-3973	94.4137	NM_018309
TBC1D23	hsa-miR-298	94.0502	NM_001199198
TBC1D23	hsa-miR-6759-3p	93.6497	NM_001199198
TBC1D23	hsa-miR-340-5p	93.1214	NM_001199198
TBC1D23	hsa-miR-4699-3p	92.3154	NM_001199198
TBC1D23	hsa-miR-551b-5p	92.0781	NM_001199198
TBC1D23	hsa-miR-6083	88.5642	NM_001199198
TBC1D23	hsa-miR-4775	88.5303	NM_001199198
TBC1D23	hsa-miR-32-3p	87.9147	NM_001199198
TBC1D23	hsa-miR-4276	87.6579	NM_018309
TBC1D23	hsa-miR-3177-5p	87.1369	NM_018309
TBC1D23	hsa-miR-590-3p	86.8285	NM_018309
TBC1D23	hsa-miR-6809-3p	85.7191	NM_001199198
TBC1D23	hsa-miR-3920	85.0147	NM_018309
TBC1D23	hsa-miR-548as-3p	84.6444	NM_001199198
TBC1D23	hsa-miR-369-3p	82.7974	NM_001199198
TBC1D23	hsa-miR-1290	82.642	NM_018309
TBC1D23	hsa-miR-5197-3p	82.3565	NM_018309
TBC1D23	hsa-miR-587	81.9613	NM_018309

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Motifs and transcription factors (TFs) regulating TBC1D23

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBC1D23	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TBC1D23	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TBC1D23	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TBC1D23	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."