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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBC1D16

Summary for TBC1D16

Gene information	Gene symbol	TBC1D16
	Ensembl ID	ENSG00000167291
	Entrez ID	125058
	Gene name	TBC1 domain family member 16
	Synonyms	FLJ20748\|MGC25062
	Gene type	protein_coding
	UniProtAcc	Q8TBP0

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Dataset with differentially expressed gene: TBC1D16

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.301941	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.344234	7.79e-24
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.322351	3.03e-13
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.327418	2.80e-19
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.506287	0.00e+00

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Expression of TBC1D16 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBC1D16

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBC1D16

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBC1D16	hsa-miR-6867-5p	99.8973	NM_001271844
TBC1D16	hsa-miR-4292	99.162	NM_001271844
TBC1D16	hsa-miR-6791-5p	99.162	NM_001271844
TBC1D16	hsa-miR-939-3p	98.4543	NM_001271845
TBC1D16	hsa-miR-3194-5p	96.8039	NM_001271845
TBC1D16	hsa-miR-5787	96.3013	NM_001271845
TBC1D16	hsa-miR-4505	96.2763	NM_001271845
TBC1D16	hsa-miR-6887-3p	95.6516	NM_001271845
TBC1D16	hsa-miR-4649-3p	94.1097	NM_001271845
TBC1D16	hsa-miR-7111-3p	94.0971	NM_001271845
TBC1D16	hsa-miR-3059-5p	93.6635	NM_001271845
TBC1D16	hsa-miR-6852-5p	93.1906	NM_001271845
TBC1D16	hsa-miR-4319	93.1327	NM_001271844
TBC1D16	hsa-miR-4664-5p	90.2185	NM_001271845
TBC1D16	hsa-miR-7113-5p	89.9295	NM_001271845
TBC1D16	hsa-miR-6826-3p	89.9024	NM_001271845
TBC1D16	hsa-miR-766-5p	89.8911	NM_001271845
TBC1D16	hsa-miR-6810-3p	89.7279	NM_001271845
TBC1D16	hsa-miR-18a-3p	88.5932	NM_001271845
TBC1D16	hsa-miR-6734-3p	88.5709	NM_001271845
TBC1D16	hsa-miR-2276-5p	88.3887	NM_001271845
TBC1D16	hsa-miR-342-5p	88.3603	NM_001271845
TBC1D16	hsa-miR-4520-2-3p	87.7162	NM_001271845
TBC1D16	hsa-miR-3667-3p	87.598	NM_001271845
TBC1D16	hsa-miR-6783-3p	87.2437	NM_001271845
TBC1D16	hsa-miR-361-3p	87.0599	NM_001271845
TBC1D16	hsa-miR-6842-3p	87.0042	NM_001271845
TBC1D16	hsa-miR-4267	86.9858	NM_001271844
TBC1D16	hsa-miR-4520-3p	86.9067	NM_001271845
TBC1D16	hsa-miR-1343-3p	86.8364	NM_001271845
TBC1D16	hsa-miR-6801-3p	86.7211	NM_001271845
TBC1D16	hsa-miR-2467-5p	86.3557	NM_001271844
TBC1D16	hsa-miR-149-5p	86.0004	NM_001271844
TBC1D16	hsa-miR-3935	85.8942	NM_001271845
TBC1D16	hsa-miR-4749-3p	85.8436	NM_001271845
TBC1D16	hsa-miR-608	85.4221	NM_001271845
TBC1D16	hsa-miR-4651	85.4221	NM_001271845
TBC1D16	hsa-miR-125a-5p	85.209	NM_001271844
TBC1D16	hsa-miR-125b-5p	85.209	NM_001271844
TBC1D16	hsa-miR-647	84.7973	NM_001271845
TBC1D16	hsa-miR-204-3p	84.7286	NM_001271846
TBC1D16	hsa-miR-4646-5p	84.7286	NM_001271846
TBC1D16	hsa-miR-6804-5p	84.1582	NM_001271844
TBC1D16	hsa-miR-7154-3p	84.0461	NM_001271845
TBC1D16	hsa-miR-324-3p	83.9166	NM_001271845
TBC1D16	hsa-miR-6742-3p	83.8521	NM_001271845
TBC1D16	hsa-miR-6780a-3p	83.498	NM_001271845
TBC1D16	hsa-miR-939-5p	83.2675	NM_001271845
TBC1D16	hsa-miR-1343-5p	83.2675	NM_001271845
TBC1D16	hsa-miR-6504-5p	82.5051	NM_001271844

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Motifs and transcription factors (TFs) regulating TBC1D16

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBC1D16	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
TBC1D16	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
TBC1D16	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
TBC1D16	tfdimers__MD00456	E2F6; OVOL2 (directAnnotation).
TBC1D16	kznf__ZNF302_Imbeault2017_RP_RCADE	ZNF302 (directAnnotation).
TBC1D16	metacluster_161.4	LHX9 (directAnnotation).
TBC1D16	kznf__ZNF737_Imbeault2017_OM_MEME	ZNF737 (directAnnotation).
TBC1D16	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TBC1D16	hdpi__ETV4	ETV4 (directAnnotation).
TBC1D16	transfac_pro__M05628	ZNF735 (directAnnotation).
TBC1D16	metacluster_98.1	ZNF524 (directAnnotation).
TBC1D16	transfac_pro__M01253	CNOT3 (directAnnotation).
TBC1D16	hdpi__NFIX	NFIX (directAnnotation).
TBC1D16	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
TBC1D16	transfac_pro__M05712	ZNF134 (directAnnotation).
TBC1D16	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."