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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TBC1D15

Summary for TBC1D15

Gene information	Gene symbol	TBC1D15
	Ensembl ID	ENSG00000121749
	Entrez ID	64786
	Gene name	TBC1 domain family member 15
	Synonyms	DKFZp761D0223\|FLJ12085
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TBC1D15

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.38154	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.271198	4.20e-45
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.393753	6.68e-23

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Expression of TBC1D15 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TBC1D15

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TBC1D15

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TBC1D15	hsa-miR-520g-3p	97.791	NM_001146213
TBC1D15	hsa-miR-520h	97.791	NM_001146213
TBC1D15	hsa-miR-4775	96.796	NM_001146213
TBC1D15	hsa-miR-126-5p	96.6952	NM_001146213
TBC1D15	hsa-miR-5692a	95.6767	NM_001146213
TBC1D15	hsa-miR-3658	95.5154	NM_001146213
TBC1D15	hsa-miR-1283	95.4023	NM_001146213
TBC1D15	hsa-miR-6787-3p	95.1063	NM_001146213
TBC1D15	hsa-miR-9-3p	93.4375	NM_001146213
TBC1D15	hsa-miR-551b-5p	93.0911	NM_001146213
TBC1D15	hsa-miR-5002-5p	92.6857	NM_022771
TBC1D15	hsa-miR-1305	91.7644	NM_001146213
TBC1D15	hsa-miR-3163	91.6759	NM_001146213
TBC1D15	hsa-miR-4436b-5p	91.6711	NM_022771
TBC1D15	hsa-miR-300	91.0282	NM_022771
TBC1D15	hsa-miR-381-3p	91.0282	NM_022771
TBC1D15	hsa-miR-4282	90.6759	NM_001146213
TBC1D15	hsa-miR-1297	90.6045	NM_001146213
TBC1D15	hsa-miR-26b-5p	89.5143	NM_001146213
TBC1D15	hsa-miR-26a-5p	89.5143	NM_001146213
TBC1D15	hsa-miR-548c-3p	89.3606	NM_001146213
TBC1D15	hsa-miR-4465	88.5557	NM_001146213
TBC1D15	hsa-miR-590-3p	88.4753	NM_022771
TBC1D15	hsa-miR-340-5p	87.8156	NM_022771
TBC1D15	hsa-miR-145-5p	87.7686	NM_001146213
TBC1D15	hsa-miR-5195-3p	87.7686	NM_001146213
TBC1D15	hsa-miR-606	87.1622	NM_001146213
TBC1D15	hsa-miR-587	87.1153	NM_022771
TBC1D15	hsa-miR-338-3p	86.8727	NM_022771
TBC1D15	hsa-miR-613	86.6697	NM_001146213
TBC1D15	hsa-miR-1-3p	86.6697	NM_001146213
TBC1D15	hsa-miR-206	86.6697	NM_001146213
TBC1D15	hsa-miR-4429	86.2723	NM_001146213
TBC1D15	hsa-miR-320d	86.2723	NM_001146213
TBC1D15	hsa-miR-320c	86.2723	NM_001146213
TBC1D15	hsa-miR-320a-3p	86.2723	NM_001146213
TBC1D15	hsa-miR-320b	86.2723	NM_001146213
TBC1D15	hsa-miR-30c-5p	86.1535	NM_001146213
TBC1D15	hsa-miR-30d-5p	86.1535	NM_001146213
TBC1D15	hsa-miR-30e-5p	86.1535	NM_001146213
TBC1D15	hsa-miR-30b-5p	86.1535	NM_001146213
TBC1D15	hsa-miR-30a-5p	86.1535	NM_001146213
TBC1D15	hsa-miR-569	86.0702	NM_001146213
TBC1D15	hsa-miR-3915	84.3578	NM_022771
TBC1D15	hsa-miR-4659a-3p	84.1818	NM_022771
TBC1D15	hsa-miR-4659b-3p	84.1818	NM_022771
TBC1D15	hsa-miR-5011-5p	83.9027	NM_022771
TBC1D15	hsa-miR-892c-5p	83.7761	NM_022771
TBC1D15	hsa-miR-506-5p	83.6792	NM_022771
TBC1D15	hsa-miR-190a-3p	82.9957	NM_022771

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Motifs and transcription factors (TFs) regulating TBC1D15

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TBC1D15	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TBC1D15	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
TBC1D15	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
TBC1D15	metacluster_191.5	SPDEF (inferredBy_Orthology).
TBC1D15	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
TBC1D15	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TBC1D15	jaspar__MA1122.1	TFDP1 (directAnnotation).
TBC1D15	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TBC1D15	hdpi__ELF2	ELF2 (directAnnotation).
TBC1D15	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."