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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TAP2

Summary for TAP2

Gene information	Gene symbol	TAP2
	Ensembl ID	ENSG00000232326
	Entrez ID	6891
	Gene name	transporter 2, ATP binding cassette subfamily B member
	Synonyms	ABCB3\|D6S217E\|PSF2\|RING11
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.312685	1.41e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.621257	1.06e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.271737	7.58e-18

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Expression of TAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TAP2	hsa-miR-146b-3p	94.9061	NM_018833
TAP2	hsa-miR-6857-5p	92.095	NM_000544
TAP2	hsa-miR-5692a	92.0608	NM_000544
TAP2	hsa-miR-4306	91.7801	NM_000544
TAP2	hsa-miR-3191-5p	91.4746	NM_000544
TAP2	hsa-miR-518c-5p	90.6869	NM_000544
TAP2	hsa-miR-4680-3p	89.9233	NM_001290043
TAP2	hsa-miR-4441	88.8704	NM_000544
TAP2	hsa-miR-4793-5p	88.567	NM_018833
TAP2	hsa-miR-4733-3p	88.4485	NM_001290043
TAP2	hsa-miR-1224-3p	87.0054	NM_018833
TAP2	hsa-miR-6733-5p	86.6521	NM_000544
TAP2	hsa-miR-6739-5p	86.6521	NM_000544
TAP2	hsa-miR-6770-5p	86.3301	NM_000544
TAP2	hsa-miR-6840-3p	84.9016	NM_018833
TAP2	hsa-miR-3153	84.4182	NM_000544
TAP2	hsa-miR-6880-5p	84.1689	NM_000544
TAP2	hsa-miR-185-5p	83.4402	NM_000544
TAP2	hsa-miR-4644	83.4402	NM_000544
TAP2	hsa-miR-1277-5p	83.2778	NM_000544
TAP2	hsa-miR-384	83.1132	NM_001290043
TAP2	hsa-miR-6516-3p	82.8124	NM_000544
TAP2	hsa-miR-4476	82.422	NM_000544
TAP2	hsa-miR-6876-5p	82.422	NM_000544
TAP2	hsa-miR-4270	81.9692	NM_000544
TAP2	hsa-miR-1252-5p	81.5399	NM_018833
TAP2	hsa-miR-200c-3p	81.2462	NM_000544
TAP2	hsa-miR-200b-3p	81.2462	NM_000544
TAP2	hsa-miR-429	81.2462	NM_000544
TAP2	hsa-miR-4271	81.0692	NM_018833
TAP2	hsa-miR-6754-5p	80.7523	NM_000544
TAP2	hsa-miR-580-5p	80.1918	NM_000544

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Motifs and transcription factors (TFs) regulating TAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TAP2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
TAP2	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
TAP2	jaspar__MA1684.1	FOXN1 (inferredBy_Orthology).
TAP2	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
TAP2	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
TAP2	metacluster_113.4	MYB; MYB; MYBL1; MYBL2 (directAnnotation). MYB; MYB; MYBL1; MYBL2 (inferredBy_Orthology).
TAP2	transfac_pro__M05803	ZNF584 (directAnnotation).
TAP2	transfac_pro__M06263	ZNF211 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."