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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TANK

Summary for TANK

Gene information	Gene symbol	TANK
	Ensembl ID	ENSG00000136560
	Entrez ID	10010
	Gene name	TRAF family member associated NFKB activator
	Synonyms	I-TRAF\|TRAF2
	Gene type	protein_coding
	UniProtAcc	Q92844

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Dataset with differentially expressed gene: TANK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.932443	5.96e-07
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.359688	3.84e-15
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.297574	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.417464	3.87e-23
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.263368	7.44e-16
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.261433	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.256237	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.416071	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.34437	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.467085	3.32e-21

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Expression of TANK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TANK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TANK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TANK	hsa-miR-5692a	96.8692	NM_001199135
TANK	hsa-miR-4482-3p	94.6515	NM_004180
TANK	hsa-miR-4464	92.9907	NM_004180
TANK	hsa-miR-4748	92.9907	NM_004180
TANK	hsa-miR-654-3p	92.6879	NM_004180
TANK	hsa-miR-337-3p	92.237	NM_001199135
TANK	hsa-miR-548c-3p	91.0815	NM_004180
TANK	hsa-miR-524-5p	90.2408	NM_004180
TANK	hsa-miR-520d-5p	90.2408	NM_004180
TANK	hsa-miR-4288	89.2676	NM_004180
TANK	hsa-miR-9902	88.1886	NM_004180
TANK	hsa-miR-3145-3p	87.5335	NM_004180
TANK	hsa-miR-190b-5p	86.162	NM_004180
TANK	hsa-miR-190a-5p	86.162	NM_004180
TANK	hsa-miR-582-5p	84.658	NM_004180
TANK	hsa-miR-632	83.6545	NM_004180
TANK	hsa-miR-126-5p	83.6002	NM_001199135
TANK	hsa-miR-12116	83.5021	NM_004180
TANK	hsa-miR-548ac	82.6964	NM_001199135
TANK	hsa-miR-548h-3p	82.6964	NM_001199135
TANK	hsa-miR-548z	82.6964	NM_001199135
TANK	hsa-miR-548d-3p	82.6964	NM_001199135
TANK	hsa-miR-548bb-3p	82.6964	NM_001199135
TANK	hsa-miR-4803	82.2874	NM_004180
TANK	hsa-miR-653-3p	81.3186	NM_004180

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Motifs and transcription factors (TFs) regulating TANK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TANK	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TANK	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TANK	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TANK	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TANK	transfac_pro__M04950	EGR1 (directAnnotation).
TANK	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TANK	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
TANK	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
TANK	cisbp__M08198	ELF1 (directAnnotation).
TANK	hdpi__ETV4	ETV4 (directAnnotation).
TANK	jaspar__MA1122.1	TFDP1 (directAnnotation).
TANK	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TANK	transfac_pro__M07387	ZBTB7A (directAnnotation).
TANK	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TANK	transfac_pro__M04893	TAF1 (directAnnotation).
TANK	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TANK	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TANK	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TANK	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TANK	cisbp__M00139	ZNF281 (inferredBy_Orthology).
TANK	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
TANK	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
TANK	metacluster_84.2	RARA (directAnnotation).
TANK	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
TANK	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
TANK	transfac_public__M00373	PAX4 (directAnnotation).
TANK	transfac_pro__M00938	E2F1 (directAnnotation).
TANK	transfac_pro__M12667	GPBP1L1 (directAnnotation).
TANK	transfac_pro__M08818	KLF8 (directAnnotation).
TANK	metacluster_135.11	NR2C2 (directAnnotation).
TANK	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TANK	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TANK	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TANK	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
TANK	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
TANK	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
TANK	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
TANK	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
TANK	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
TANK	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
TANK	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
TANK	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TANK	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
TANK	tfdimers__MD00456	E2F6; OVOL2 (directAnnotation).
TANK	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
TANK	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).
TANK	cisbp__M00809	PRDM11 (inferredBy_Orthology).
TANK	hdpi__NRL	NRL (directAnnotation).
TANK	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
TANK	transfac_public__M00040	ATF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."