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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TANGO2

Summary for TANGO2

Gene information	Gene symbol	TANGO2
	Ensembl ID	ENSG00000183597
	Entrez ID	128989
	Gene name	transport and golgi organization 2 homolog
	Synonyms	C22orf25\|DKFZp761P1121
	Gene type	protein_coding
	UniProtAcc	Q6ICL3

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Dataset with differentially expressed gene: TANGO2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.38837	5.97e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.659401	0.00e+00

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Expression of TANGO2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TANGO2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TANGO2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TANGO2	hsa-miR-6867-5p	98.7559	NM_001283248
TANGO2	hsa-miR-5189-5p	90.2657	NM_001283116
TANGO2	hsa-miR-1285-3p	90.2657	NM_001283116
TANGO2	hsa-miR-3187-5p	90.1808	NM_001283116
TANGO2	hsa-miR-122b-3p	89.3131	NM_001283116
TANGO2	hsa-miR-21-3p	89.3131	NM_001283116
TANGO2	hsa-miR-6849-3p	88.87	NM_001283116
TANGO2	hsa-miR-4326	88.5558	NM_001283116
TANGO2	hsa-miR-612	88.0562	NM_001283116
TANGO2	hsa-miR-6860	88.034	NM_001283116
TANGO2	hsa-miR-3194-3p	86.919	NM_001283248
TANGO2	hsa-miR-371b-5p	82.4848	NM_001283116
TANGO2	hsa-miR-373-5p	82.4848	NM_001283116
TANGO2	hsa-miR-616-5p	82.4848	NM_001283116
TANGO2	hsa-miR-6748-3p	82.1205	NM_001283248

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Motifs and transcription factors (TFs) regulating TANGO2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TANGO2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TANGO2	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
TANGO2	transfac_pro__M05521	ZNF398 (directAnnotation).
TANGO2	metacluster_168.18	ZNF214; ZNF239; ZNF45; ZNF696 (directAnnotation).
TANGO2	transfac_pro__M05539	OSR2 (inferredBy_Orthology).
TANGO2	kznf__SP1_Transfac.3_Transfac	SP1 (directAnnotation).
TANGO2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
TANGO2	transfac_pro__M06642	ZSCAN10 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."