Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE186960 | Panc1 cell line | Cell line | Pancreatic cancer | Pancreatic ductal adenocarcinoma (PDAC) | Chemotherapy | gemcitabine | NA | Malignant cells | -0.922344 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | post | Plasma cells | -0.464692 | 1.79e-14 |
GSE169246_PacAteTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Immunotherapy | atezolizumab + paclitaxel | pre | B cells | -0.29135 | 1.42e-06 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Malignant cells | -0.256368 | 3.42e-03 |
GSE168668 | LNCaP cell line | Cell line | Prostate cancer | Prostate cancer | Targeted therapy | enzalutamide | NA | Malignant cells | -0.575165 | 0.00e+00 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | -0.335955 | 0.00e+00 |
GSE164897_VemCob | A375 cell line | Cell line | Melanoma | BRAFV600E-mutant melanoma | Targeted therapy | vemurafenib + combimetinib | NA | Malignant cells | -0.317675 | 0.00e+00 |
GSE164897_VemTra | A375 cell line | Cell line | Melanoma | B+E2:E57RAFV600E-mutant melanoma | Targeted therapy | vemurafenib + trametinib | NA | Malignant cells | -0.428182 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
TAF1D | metacluster_7.13 | ZFX (directAnnotation). |
TAF1D | cisbp__M01863 | ZNF711 (inferredBy_Orthology). |
TAF1D | metacluster_155.23 | BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology). |
TAF1D | hdpi__ETV4 | ETV4 (directAnnotation). |
TAF1D | homer__TWVGGTCCGC_HINFP | HINFP (directAnnotation). |
TAF1D | hdpi__TP73 | TP73 (directAnnotation). |
TAF1D | metacluster_138.2 | ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology). |
TAF1D | cisbp__M02645 | ETS1 (directAnnotation). |
TAF1D | metacluster_33.8 | BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology). |
TAF1D | cisbp__M08198 | ELF1 (directAnnotation). |
TAF1D | transfac_pro__M04862 | NRF1 (directAnnotation). |
TAF1D | metacluster_182.10 | ZFX (directAnnotation). |
TAF1D | taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP | ETV5; FOXI1 (directAnnotation). |
TAF1D | hdpi__FLI1 | FLI1 (directAnnotation). |
TAF1D | taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP | ETV1; HOXB2 (directAnnotation). |
TAF1D | taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP | ETV1; TEAD4 (directAnnotation). |
TAF1D | transfac_pro__M04748 | GABPA (directAnnotation). |
TAF1D | taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr | ERF; FOXI1 (directAnnotation). |
TAF1D | taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP | ELK1; FOXO1 (directAnnotation). |
TAF1D | taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP | ERG; TEAD4 (directAnnotation). |
TAF1D | transfac_pro__M02861 | GATA6 (inferredBy_Orthology). |
TAF1D | metacluster_21.4 | HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology). |
TAF1D | metacluster_22.29 | NFE2 (directAnnotation). |
TAF1D | metacluster_30.4 | BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation). |
TAF1D | transfac_pro__M06052 | ZNF729 (directAnnotation). |
TAF1D | transfac_pro__M05785 | ZNF48 (inferredBy_Orthology). |
TAF1D | transfac_pro__M06369 | ZFP1 (directAnnotation). |
TAF1D | tfdimers__MD00432 | DBP; STAT1 (directAnnotation). |
TAF1D | transfac_pro__M04887 | TCF12 (directAnnotation). |
TAF1D | metacluster_141.9 | TAF1; YY1; YY1 (directAnnotation). |
TAF1D | hocomoco__OTX1_HUMAN.H11MO.0.D | OTX1 (directAnnotation). |
TAF1D | transfac_pro__M04886 | ETS1 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |