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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TAF15

Summary for TAF15

Gene information	Gene symbol	TAF15
	Ensembl ID	ENSG00000276833
	Entrez ID	8148
	Gene name	TATA-box binding protein associated factor 15
	Synonyms	hTAFII68\|Npl3\|RBP56\|TAF2N
	Gene type	protein_coding
	UniProtAcc	Q92804

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Dataset with differentially expressed gene: TAF15

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.76443	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.361335	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.334804	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.278997	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.28596	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.29388	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.349332	0.00e+00

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Expression of TAF15 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TAF15

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TAF15

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TAF15	hsa-miR-182-5p	92.4664	NM_139215
TAF15	hsa-miR-6763-5p	88.3746	NM_139215
TAF15	hsa-miR-3150a-3p	88.3746	NM_139215
TAF15	hsa-miR-4756-3p	82.5272	NM_003487
TAF15	hsa-miR-3919	82.5272	NM_003487
TAF15	hsa-miR-4999-3p	80.0582	NM_139215

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Motifs and transcription factors (TFs) regulating TAF15

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TAF15	metacluster_7.13	ZFX (directAnnotation).
TAF15	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TAF15	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
TAF15	metacluster_151.2	ZNF23 (directAnnotation).
TAF15	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TAF15	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TAF15	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TAF15	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TAF15	hdpi__ETV4	ETV4 (directAnnotation).
TAF15	transfac_pro__M06071	ZNF814 (directAnnotation).
TAF15	jaspar__MA0748.2	YY2 (directAnnotation).
TAF15	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
TAF15	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TAF15	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TAF15	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
TAF15	jaspar__MA0079.5	SP1 (directAnnotation).
TAF15	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
TAF15	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TAF15	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TAF15	transfac_pro__M07397	ZNF148 (directAnnotation).
TAF15	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TAF15	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
TAF15	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TAF15	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TAF15	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TAF15	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TAF15	transfac_pro__M01175	ZBTB7B (directAnnotation).
TAF15	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TAF15	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TAF15	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TAF15	transfac_pro__M01303	SP1 (directAnnotation).
TAF15	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TAF15	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TAF15	transfac_pro__M02090	E2F4 (directAnnotation).
TAF15	transfac_pro__M01714	KLF15 (directAnnotation).
TAF15	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TAF15	jaspar__MA1122.1	TFDP1 (directAnnotation).
TAF15	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TAF15	transfac_pro__M02089	E2F3 (directAnnotation).
TAF15	metacluster_3.14	WT1; WT1 (directAnnotation).
TAF15	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TAF15	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
TAF15	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TAF15	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TAF15	cisbp__M07938	E2F1 (directAnnotation).
TAF15	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TAF15	transfac_pro__M07436	WT1 (directAnnotation).
TAF15	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TAF15	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TAF15	transfac_pro__M02898	SMAD3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."