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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: TAF11

Summary for TAF11

Gene informationGene symbol

TAF11

Ensembl ID

ENSG00000064995

Entrez ID

6882

Gene nameTATA-box binding protein associated factor 11
SynonymsTAF2I|TAFII28
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: TAF11

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD8+ T cells-0.3367060.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells-0.3447150.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells-0.3494580.00e+00

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells-0.2817382.67e-11

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Expression of TAF11 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to TAF11

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TAF11

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
TAF11hsa-miR-29c-3p93.0308NM_001270488
TAF11hsa-miR-29a-3p93.0308NM_001270488
TAF11hsa-miR-29b-3p93.0308NM_001270488
TAF11hsa-miR-125b-2-3p91.2209NM_005643
TAF11hsa-miR-450490.7412NM_005643
TAF11hsa-miR-318590.6071NM_001270488
TAF11hsa-miR-4768-3p89.8855NM_005643
TAF11hsa-miR-6873-3p88.783NM_005643
TAF11hsa-miR-314887.2485NM_001270488
TAF11hsa-miR-397885.6251NM_001270488
TAF11hsa-miR-6817-3p85.4153NM_005643
TAF11hsa-miR-60185.0325NM_001270488
TAF11hsa-miR-612484.8797NM_001270488
TAF11hsa-miR-6833-3p84.6023NM_005643
TAF11hsa-miR-445181.3359NM_005643
TAF11hsa-miR-371a-5p80.6576NM_005643
TAF11hsa-miR-4768-5p80.0595NM_005643
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Motifs and transcription factors (TFs) regulating TAF11

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
TAF11taipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
TAF11metacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TAF11jaspar__MA1483.2ELF2 (directAnnotation).
TAF11taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_reprELF1; MEIS1 (directAnnotation).
TAF11taipale_tf_pairs__ELF2_NATGCGGAAGTR_HTELF2 (directAnnotation).
TAF11cisbp__M08198ELF1 (directAnnotation).
TAF11metacluster_81.7CREB1 (directAnnotation).
Page: 1

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."