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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TAB2

Summary for TAB2

Gene information	Gene symbol	TAB2
	Ensembl ID	ENSG00000055208
	Entrez ID	23118
	Gene name	TGF-beta activated kinase 1 (MAP3K7) binding protein 2
	Synonyms	KIAA0733\|MAP3K7IP2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TAB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.276761	1.14e-17
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.586623	0.00e+00

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Expression of TAB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TAB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TAB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TAB2	hsa-miR-520d-5p	99.2339	NM_001292035
TAB2	hsa-miR-524-5p	99.2339	NM_001292035
TAB2	hsa-miR-6875-3p	97.8246	NM_001292034
TAB2	hsa-let-7a-2-3p	97.2645	NM_001292034
TAB2	hsa-let-7g-3p	97.2645	NM_001292034
TAB2	hsa-miR-6073	95.8804	NM_001292034
TAB2	hsa-miR-6754-3p	95.7594	NM_001292034
TAB2	hsa-miR-302c-5p	95.1854	NM_001292035
TAB2	hsa-miR-7-5p	95.0051	NM_001292034
TAB2	hsa-miR-194-3p	94.9655	NM_001292034
TAB2	hsa-miR-7162-3p	94.8604	NM_001292034
TAB2	hsa-miR-134-3p	94.7911	NM_001292034
TAB2	hsa-miR-4326	94.0066	NM_001292034
TAB2	hsa-miR-4255	93.1695	NM_001292034
TAB2	hsa-miR-412-3p	93.0315	NM_001292034
TAB2	hsa-miR-6837-3p	93.0315	NM_001292034
TAB2	hsa-miR-3922-5p	92.9412	NM_001292035
TAB2	hsa-miR-6793-5p	91.8405	NM_001292034
TAB2	hsa-miR-2355-3p	91.8135	NM_001292034
TAB2	hsa-miR-4293	91.7567	NM_001292034
TAB2	hsa-miR-142-3p	91.0132	NM_001292034
TAB2	hsa-miR-140-3p	90.8728	NM_001292034
TAB2	hsa-miR-136-3p	90.6325	NM_001292035
TAB2	hsa-miR-6847-3p	90.4941	NM_001292034
TAB2	hsa-miR-676-3p	90.3839	NM_001292034
TAB2	hsa-miR-4291	89.5491	NM_001292034
TAB2	hsa-miR-4323	89.5341	NM_001292034
TAB2	hsa-miR-3148	89.2534	NM_001292035
TAB2	hsa-miR-155-5p	89.0938	NM_001292034
TAB2	hsa-miR-3667-3p	88.703	NM_001292034
TAB2	hsa-miR-222-5p	87.8636	NM_001292034
TAB2	hsa-miR-4656	87.5614	NM_001292034
TAB2	hsa-miR-1284	87.4369	NM_001292034
TAB2	hsa-miR-4775	87.1736	NM_001292035
TAB2	hsa-miR-5003-3p	87.062	NM_001292035
TAB2	hsa-miR-767-3p	86.9147	NM_001292034
TAB2	hsa-miR-12128	86.7929	NM_001292034
TAB2	hsa-miR-1587	86.7812	NM_001292034
TAB2	hsa-miR-4262	86.6674	NM_001292034
TAB2	hsa-miR-124-5p	85.7362	NM_001292034
TAB2	hsa-miR-3143	85.6073	NM_001292035
TAB2	hsa-miR-199a-3p	85.5938	NM_001292034
TAB2	hsa-miR-3129-5p	85.5938	NM_001292034
TAB2	hsa-miR-199b-3p	85.5938	NM_001292034
TAB2	hsa-miR-8063	85.5656	NM_001292035
TAB2	hsa-miR-202-3p	85.3305	NM_001292034
TAB2	hsa-miR-6888-3p	85.0007	NM_001292034
TAB2	hsa-miR-4659a-3p	84.3748	NM_001292034
TAB2	hsa-miR-4659b-3p	84.3748	NM_001292034
TAB2	hsa-miR-4741	84.2012	NM_001292034

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Motifs and transcription factors (TFs) regulating TAB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TAB2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TAB2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TAB2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
TAB2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TAB2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
TAB2	transfac_pro__M00652	NRF1 (directAnnotation).
TAB2	transfac_pro__M01298	MECP2 (directAnnotation).
TAB2	transfac_pro__M04918	EGR1 (directAnnotation).
TAB2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TAB2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
TAB2	metacluster_7.13	ZFX (directAnnotation).
TAB2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TAB2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
TAB2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TAB2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TAB2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TAB2	cisbp__M00249	WT1 (directAnnotation).
TAB2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TAB2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TAB2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TAB2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TAB2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TAB2	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
TAB2	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."