Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYT4

Summary for SYT4

Gene information	Gene symbol	SYT4
	Ensembl ID	ENSG00000132872
	Entrez ID	6860
	Gene name	synaptotagmin 4
	Synonyms	HsT1192\|KIAA1342
	Gene type	protein_coding
	UniProtAcc	Q9H2B2

Top

Dataset with differentially expressed gene: SYT4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.56872	0.00e+00

Top

Expression of SYT4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SYT4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SYT4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYT4	hsa-miR-3529-3p	99.5357	NM_020783
SYT4	hsa-miR-550a-3p	98.3734	NM_020783
SYT4	hsa-miR-524-5p	98.3682	NM_020783
SYT4	hsa-miR-520d-5p	98.3682	NM_020783
SYT4	hsa-miR-200c-5p	97.714	NM_020783
SYT4	hsa-miR-627-3p	97.5203	NM_020783
SYT4	hsa-miR-4775	97.3711	NM_020783
SYT4	hsa-miR-548x-3p	96.9568	NM_020783
SYT4	hsa-miR-548aj-3p	96.9568	NM_020783
SYT4	hsa-miR-548am-3p	96.6926	NM_020783
SYT4	hsa-miR-548ae-3p	96.6926	NM_020783
SYT4	hsa-miR-548ah-3p	96.6926	NM_020783
SYT4	hsa-miR-548aq-3p	96.6926	NM_020783
SYT4	hsa-miR-548j-3p	96.6926	NM_020783
SYT4	hsa-miR-590-3p	94.2594	NM_020783
SYT4	hsa-miR-374c-5p	94.2045	NM_020783
SYT4	hsa-miR-655-3p	94.2045	NM_020783
SYT4	hsa-miR-548ac	94.1524	NM_020783
SYT4	hsa-miR-548z	94.1524	NM_020783
SYT4	hsa-miR-548d-3p	94.1524	NM_020783
SYT4	hsa-miR-548h-3p	94.1524	NM_020783
SYT4	hsa-miR-548bb-3p	94.1524	NM_020783
SYT4	hsa-miR-888-5p	94.1376	NM_020783
SYT4	hsa-miR-4666a-5p	93.7183	NM_020783
SYT4	hsa-miR-30a-3p	93.0811	NM_020783
SYT4	hsa-miR-30d-3p	93.0811	NM_020783
SYT4	hsa-miR-30e-3p	93.0811	NM_020783
SYT4	hsa-miR-12123	92.8804	NM_020783
SYT4	hsa-miR-876-5p	92.5892	NM_020783
SYT4	hsa-miR-3167	92.0888	NM_020783
SYT4	hsa-miR-6835-3p	91.8647	NM_020783
SYT4	hsa-miR-3671	91.8546	NM_020783
SYT4	hsa-miR-5004-3p	91.7448	NM_020783
SYT4	hsa-miR-5003-3p	90.9945	NM_020783
SYT4	hsa-miR-6760-3p	89.7662	NM_020783
SYT4	hsa-miR-1290	89.2293	NM_020783
SYT4	hsa-miR-4753-3p	88.9698	NM_020783
SYT4	hsa-miR-5186	88.3832	NM_020783
SYT4	hsa-miR-4422	88.3171	NM_020783
SYT4	hsa-miR-9-5p	87.921	NM_020783
SYT4	hsa-miR-466	87.8858	NM_020783
SYT4	hsa-miR-493-5p	87.7368	NM_020783
SYT4	hsa-miR-589-3p	87.078	NM_020783
SYT4	hsa-miR-382-5p	86.5436	NM_020783
SYT4	hsa-miR-371b-5p	86.3295	NM_020783
SYT4	hsa-miR-373-5p	86.3295	NM_020783
SYT4	hsa-miR-616-5p	86.3295	NM_020783
SYT4	hsa-miR-448	86.1804	NM_020783
SYT4	hsa-miR-29b-2-5p	86.0579	NM_020783
SYT4	hsa-miR-513b-5p	85.6769	NM_020783

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating SYT4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."