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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYT14

Summary for SYT14

Gene information	Gene symbol	SYT14
	Ensembl ID	ENSG00000143469
	Entrez ID	255928
	Gene name	synaptotagmin 14
	Synonyms	FLJ34198\|sytXIV
	Gene type	protein_coding
	UniProtAcc	Q8NB59

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Dataset with differentially expressed gene: SYT14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.92025	2.17e-02

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Expression of SYT14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SYT14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SYT14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYT14	hsa-miR-4766-5p	99.6724	NM_153262
SYT14	hsa-miR-335-3p	99.3588	NM_153262
SYT14	hsa-miR-3908	98.7492	NM_153262
SYT14	hsa-miR-5009-3p	96.838	NM_153262
SYT14	hsa-miR-4325	96.6457	NM_001146261
SYT14	hsa-miR-5692b	96.5892	NM_153262
SYT14	hsa-miR-5692c	96.5892	NM_153262
SYT14	hsa-miR-3662	95.1565	NM_001146261
SYT14	hsa-miR-421	94.8399	NM_153262
SYT14	hsa-miR-607	94.7797	NM_001146261
SYT14	hsa-miR-887-5p	94.6851	NM_153262
SYT14	hsa-miR-3646	94.3627	NM_153262
SYT14	hsa-miR-4307	92.7712	NM_153262
SYT14	hsa-miR-3133	92.3453	NM_153262
SYT14	hsa-miR-155-3p	92.297	NM_001146261
SYT14	hsa-miR-944	92.1263	NM_153262
SYT14	hsa-miR-4422	91.6193	NM_153262
SYT14	hsa-miR-7-1-3p	91.4885	NM_153262
SYT14	hsa-miR-7-2-3p	91.4885	NM_153262
SYT14	hsa-miR-4660	91.2399	NM_001146261
SYT14	hsa-miR-30c-2-3p	90.9699	NM_153262
SYT14	hsa-miR-6788-5p	90.9699	NM_153262
SYT14	hsa-miR-30c-1-3p	90.9699	NM_153262
SYT14	hsa-miR-30a-3p	90.616	NM_153262
SYT14	hsa-miR-30e-3p	90.616	NM_153262
SYT14	hsa-miR-30d-3p	90.616	NM_153262
SYT14	hsa-miR-4650-3p	90.4431	NM_001146261
SYT14	hsa-miR-3140-3p	90.2128	NM_153262
SYT14	hsa-miR-6505-5p	90.2079	NM_001146261
SYT14	hsa-miR-6882-3p	90.1791	NM_001146261
SYT14	hsa-miR-4468	89.138	NM_001146261
SYT14	hsa-miR-6770-5p	88.7565	NM_153262
SYT14	hsa-miR-12136	88.1144	NM_153262
SYT14	hsa-miR-3685	87.9062	NM_001146261
SYT14	hsa-miR-6835-3p	87.6993	NM_001146261
SYT14	hsa-miR-6885-3p	87.1476	NM_153262
SYT14	hsa-miR-507	86.9429	NM_153262
SYT14	hsa-miR-3915	86.4405	NM_001146261
SYT14	hsa-miR-4314	86.2851	NM_001146261
SYT14	hsa-miR-4773	85.877	NM_153262
SYT14	hsa-miR-6878-5p	85.6074	NM_153262
SYT14	hsa-miR-7162-5p	84.8668	NM_001146261
SYT14	hsa-miR-516b-3p	84.8668	NM_001146261
SYT14	hsa-miR-516a-3p	84.8668	NM_001146261
SYT14	hsa-miR-1277-5p	84.8416	NM_153262
SYT14	hsa-miR-4282	84.4114	NM_153262
SYT14	hsa-miR-5692a	84.1714	NM_153262
SYT14	hsa-miR-374a-5p	83.1895	NM_153262
SYT14	hsa-miR-5582-5p	82.6555	NM_001146261
SYT14	hsa-miR-582-3p	82.311	NM_153262

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Motifs and transcription factors (TFs) regulating SYT14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."