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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYT1

Summary for SYT1

Gene information	Gene symbol	SYT1
	Ensembl ID	ENSG00000067715
	Entrez ID	6857
	Gene name	synaptotagmin 1
	Synonyms	P65\|SVP65\|SYT
	Gene type	protein_coding
	UniProtAcc	P21579

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Dataset with differentially expressed gene: SYT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.69221	8.97e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.752962	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.360469	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.35438	9.16e-05
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.94081	0.00e+00

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Expression of SYT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SYT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SYT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYT1	hsa-miR-4672	99.5003	NM_001135805
SYT1	hsa-miR-1276	99.3589	NM_001135805
SYT1	hsa-miR-7162-5p	99.1482	NM_001135805
SYT1	hsa-miR-8485	99.1019	NM_005639
SYT1	hsa-miR-34a-5p	99.0398	NM_001135805
SYT1	hsa-miR-449a	99.0398	NM_001135805
SYT1	hsa-miR-516a-3p	98.8804	NM_001135805
SYT1	hsa-miR-516b-3p	98.8804	NM_001135805
SYT1	hsa-miR-449b-5p	98.7243	NM_001135805
SYT1	hsa-miR-34c-5p	98.7243	NM_001135805
SYT1	hsa-miR-2113	97.3398	NM_001135805
SYT1	hsa-miR-6842-3p	97.0429	NM_001135805
SYT1	hsa-miR-19a-3p	97.0377	NM_005639
SYT1	hsa-miR-19b-3p	97.0377	NM_005639
SYT1	hsa-miR-6768-5p	96.7687	NM_001135805
SYT1	hsa-miR-4666a-3p	96.6659	NM_001135805
SYT1	hsa-miR-4474-3p	95.9299	NM_001135805
SYT1	hsa-miR-2355-3p	95.8768	NM_001135805
SYT1	hsa-miR-4430	95.8008	NM_001135805
SYT1	hsa-miR-3652	95.8008	NM_001135805
SYT1	hsa-miR-624-5p	95.1491	NM_001135805
SYT1	hsa-miR-137-3p	94.7529	NM_001135805
SYT1	hsa-miR-4789-5p	94.549	NM_005639
SYT1	hsa-miR-676-3p	94.4205	NM_001135805
SYT1	hsa-miR-153-5p	94.388	NM_005639
SYT1	hsa-miR-1283	94.1729	NM_005639
SYT1	hsa-miR-3529-3p	94.1507	NM_001135805
SYT1	hsa-miR-1279	93.8388	NM_001135805
SYT1	hsa-miR-7162-3p	93.355	NM_001135805
SYT1	hsa-miR-12132	93.249	NM_005639
SYT1	hsa-miR-3163	92.8707	NM_001135805
SYT1	hsa-miR-711	92.8488	NM_001135805
SYT1	hsa-miR-4514	92.576	NM_001135805
SYT1	hsa-miR-4692	92.5673	NM_001135805
SYT1	hsa-miR-4505	92.3023	NM_001135805
SYT1	hsa-miR-5787	92.3023	NM_001135805
SYT1	hsa-miR-3662	90.6745	NM_005639
SYT1	hsa-miR-6072	90.6247	NM_005639
SYT1	hsa-miR-6891-3p	90.6247	NM_005639
SYT1	hsa-miR-3689a-5p	90.2884	NM_001135805
SYT1	hsa-miR-3689e	90.2884	NM_001135805
SYT1	hsa-miR-3689f	90.2884	NM_001135805
SYT1	hsa-miR-3689b-5p	90.2884	NM_001135805
SYT1	hsa-miR-1-3p	90.2831	NM_001135805
SYT1	hsa-miR-206	90.2831	NM_001135805
SYT1	hsa-miR-664a-5p	89.7764	NM_001135805
SYT1	hsa-miR-4794	89.7764	NM_001135805
SYT1	hsa-miR-892b	89.0999	NM_005639
SYT1	hsa-miR-613	89.0183	NM_001135805
SYT1	hsa-miR-889-5p	88.984	NM_001135805

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Motifs and transcription factors (TFs) regulating SYT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SYT1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SYT1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
SYT1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SYT1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SYT1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SYT1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SYT1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
SYT1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SYT1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SYT1	metacluster_3.14	WT1; WT1 (directAnnotation).
SYT1	cisbp__M07938	E2F1 (directAnnotation).
SYT1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SYT1	transfac_pro__M05481	ZNF202 (directAnnotation).
SYT1	taipale_tf_pairs__MYBL1_ELF1_NMCCGGAACCGTTR_CAP_repr	ELF1; MYBL1 (directAnnotation).
SYT1	transfac_pro__M05522	ZNF341 (directAnnotation).
SYT1	transfac_pro__M05298	OVOL3 (directAnnotation).
SYT1	metacluster_33.5	MTF1 (inferredBy_Orthology).
SYT1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
SYT1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SYT1	metacluster_168.1	ZSCAN16 (directAnnotation).
SYT1	tfdimers__MD00295	EBF1; STAT6 (directAnnotation).
SYT1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SYT1	transfac_pro__M04617	ZBTB7A (directAnnotation).
SYT1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SYT1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
SYT1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SYT1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SYT1	transfac_pro__M07387	ZBTB7A (directAnnotation).
SYT1	transfac_pro__M07436	WT1 (directAnnotation).
SYT1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SYT1	transfac_pro__M00716	ZBTB14 (directAnnotation).
SYT1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SYT1	hdpi__HIP2	UBE2K (directAnnotation).
SYT1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SYT1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SYT1	transfac_pro__M04893	TAF1 (directAnnotation).
SYT1	transfac_pro__M03876	ZBTB33 (directAnnotation).
SYT1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SYT1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SYT1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SYT1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SYT1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SYT1	tfdimers__MD00292	HLTF; POU5F1 (directAnnotation).
SYT1	hdpi__PURG	PURG (directAnnotation).
SYT1	transfac_pro__M06827	ZBTB11 (directAnnotation).
SYT1	transfac_pro__M06692	PRDM10 (directAnnotation).
SYT1	transfac_pro__M06952	BATF (directAnnotation).
SYT1	metacluster_131.3	ZNF436 (inferredBy_Orthology).
SYT1	transfac_pro__M06959	ZNF425 (directAnnotation).
SYT1	transfac_pro__M06353	ZNF782 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."