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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYS1

Summary for SYS1

Gene information	Gene symbol	SYS1
	Ensembl ID	ENSG00000204070
	Entrez ID	90196
	Gene name	SYS1 golgi trafficking protein
	Synonyms	C20orf169\|dJ453C12.4
	Gene type	protein_coding
	UniProtAcc	Q8N2H4

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Dataset with differentially expressed gene: SYS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.819826	1.56e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.325059	1.48e-33
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.300716	0.00e+00

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Expression of SYS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SYS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SYS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYS1	hsa-miR-4645-3p	93.7809	NM_001099791
SYS1	hsa-miR-330-5p	90.9833	NM_001197129
SYS1	hsa-miR-12132	89.8536	NM_001197129
SYS1	hsa-miR-548c-3p	89.5195	NM_001197129
SYS1	hsa-miR-670-3p	87.6923	NM_001099791
SYS1	hsa-miR-4474-3p	86.7858	NM_001197129
SYS1	hsa-miR-1283	86.49	NM_001099791
SYS1	hsa-miR-326	86.2237	NM_001197129
SYS1	hsa-miR-6833-3p	83.1701	NM_001197129
SYS1	hsa-miR-500b-5p	83.0819	NM_001197129
SYS1	hsa-miR-362-5p	83.0819	NM_001197129
SYS1	hsa-miR-6069	82.7734	NM_001099791
SYS1	hsa-miR-4258	82.6254	NM_001197129
SYS1	hsa-miR-6873-3p	82.3449	NM_001197129
SYS1	hsa-miR-7111-3p	81.0125	NM_001197129
SYS1	hsa-miR-4795-3p	80.9699	NM_001197129
SYS1	hsa-miR-519a-2-5p	80.7702	NM_001099791
SYS1	hsa-miR-520b-5p	80.7702	NM_001099791
SYS1	hsa-miR-6764-5p	80.6595	NM_001197129
SYS1	hsa-miR-760	80.4909	NM_001099791
SYS1	hsa-miR-6893-5p	80.3757	NM_001197129
SYS1	hsa-miR-6808-5p	80.3757	NM_001197129
SYS1	hsa-miR-940	80.3757	NM_001197129

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Motifs and transcription factors (TFs) regulating SYS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SYS1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SYS1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SYS1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SYS1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SYS1	jaspar__MA1708.1	ETV7 (directAnnotation).
SYS1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
SYS1	metacluster_161.4	LHX9 (directAnnotation).
SYS1	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
SYS1	metacluster_161.3	LHX9 (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."