Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYPL1

Summary for SYPL1

Gene information	Gene symbol	SYPL1
	Ensembl ID	ENSG00000008282
	Entrez ID	6856
	Gene name	synaptophysin like 1
	Synonyms	SYPL
	Gene type	protein_coding
	UniProtAcc	Q16563

Top

Dataset with differentially expressed gene: SYPL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.25719	4.12e-39
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.311742	3.39e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.283207	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.605882	9.84e-03
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.324806	6.11e-10

Top

Expression of SYPL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SYPL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SYPL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYPL1	hsa-miR-3685	96.9998	NM_006754
SYPL1	hsa-miR-218-2-3p	95.2769	NM_006754
SYPL1	hsa-miR-3529-3p	94.9837	NM_006754
SYPL1	hsa-miR-513a-3p	93.4479	NM_006754
SYPL1	hsa-miR-513c-3p	93.4479	NM_006754
SYPL1	hsa-miR-3606-3p	91.973	NM_006754
SYPL1	hsa-miR-6844	90.8942	NM_006754
SYPL1	hsa-miR-30b-5p	90.8096	NM_006754
SYPL1	hsa-miR-30a-5p	90.8096	NM_006754
SYPL1	hsa-miR-30c-5p	90.8096	NM_006754
SYPL1	hsa-miR-30e-5p	90.8096	NM_006754
SYPL1	hsa-miR-30d-5p	90.8096	NM_006754
SYPL1	hsa-miR-3074-5p	90.6666	NM_006754
SYPL1	hsa-miR-10527-5p	90.1579	NM_006754
SYPL1	hsa-miR-4325	89.9314	NM_006754
SYPL1	hsa-miR-196a-3p	89.2588	NM_006754
SYPL1	hsa-miR-5696	89.2077	NM_006754
SYPL1	hsa-miR-142-3p	88.6814	NM_006754
SYPL1	hsa-miR-365b-3p	88.502	NM_006754
SYPL1	hsa-miR-365a-3p	88.502	NM_006754
SYPL1	hsa-miR-155-3p	87.7211	NM_006754
SYPL1	hsa-miR-338-5p	86.7305	NM_006754
SYPL1	hsa-miR-497-5p	86.3745	NM_006754
SYPL1	hsa-miR-195-5p	86.3745	NM_006754
SYPL1	hsa-miR-6838-5p	86.3745	NM_006754
SYPL1	hsa-miR-15b-5p	86.3745	NM_006754
SYPL1	hsa-miR-15a-5p	86.3745	NM_006754
SYPL1	hsa-miR-16-5p	86.3745	NM_006754
SYPL1	hsa-miR-424-5p	86.3745	NM_006754
SYPL1	hsa-miR-607	86.146	NM_006754
SYPL1	hsa-miR-182-5p	84.2262	NM_006754
SYPL1	hsa-miR-664b-3p	83.7837	NM_006754
SYPL1	hsa-miR-579-3p	83.7837	NM_006754
SYPL1	hsa-miR-3606-5p	83.7041	NM_006754
SYPL1	hsa-miR-10395-3p	83.4252	NM_006754
SYPL1	hsa-miR-548aw	83.125	NM_006754
SYPL1	hsa-miR-514b-5p	83.0093	NM_006754
SYPL1	hsa-miR-539-3p	82.9363	NM_006754
SYPL1	hsa-miR-485-3p	82.9363	NM_006754
SYPL1	hsa-miR-1322	82.9175	NM_006754
SYPL1	hsa-miR-4477a	82.6624	NM_006754
SYPL1	hsa-miR-4803	80.958	NM_006754
SYPL1	hsa-miR-3065-5p	80.8343	NM_006754
SYPL1	hsa-miR-34c-3p	80.2198	NM_006754

Page: 1

Top

Motifs and transcription factors (TFs) regulating SYPL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SYPL1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SYPL1	hdpi__FLI1	FLI1 (directAnnotation).
SYPL1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SYPL1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SYPL1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
SYPL1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SYPL1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SYPL1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
SYPL1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SYPL1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SYPL1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
SYPL1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SYPL1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SYPL1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
SYPL1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
SYPL1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
SYPL1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
SYPL1	transfac_pro__M04950	EGR1 (directAnnotation).
SYPL1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SYPL1	transfac_pro__M06032	ZNF727 (directAnnotation).
SYPL1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
SYPL1	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
SYPL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SYPL1	metacluster_183.3	EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology).
SYPL1	metacluster_183.4	ETS1 (inferredBy_Orthology).
SYPL1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
SYPL1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
SYPL1	hdpi__ELF2	ELF2 (directAnnotation).
SYPL1	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
SYPL1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SYPL1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SYPL1	metacluster_81.7	CREB1 (directAnnotation).
SYPL1	transfac_pro__M01298	MECP2 (directAnnotation).
SYPL1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SYPL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SYPL1	transfac_pro__M12697	ZNF142 (directAnnotation).
SYPL1	metacluster_151.2	ZNF23 (directAnnotation).
SYPL1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
SYPL1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SYPL1	transfac_pro__M06035	ZNF749 (directAnnotation).
SYPL1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SYPL1	cisbp__M07938	E2F1 (directAnnotation).
SYPL1	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
SYPL1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SYPL1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SYPL1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SYPL1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
SYPL1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SYPL1	transfac_pro__M01253	CNOT3 (directAnnotation).
SYPL1	transfac_pro__M02090	E2F4 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."