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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYNPO

Summary for SYNPO

Gene information	Gene symbol	SYNPO
	Ensembl ID	ENSG00000171992
	Entrez ID	11346
	Gene name	synaptopodin
	Synonyms	KIAA1029
	Gene type	protein_coding
	UniProtAcc	Q8N3V7

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Dataset with differentially expressed gene: SYNPO

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.291763	3.14e-13

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Expression of SYNPO in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SYNPO

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SYNPO

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYNPO	hsa-miR-6867-5p	100	NM_007286
SYNPO	hsa-miR-1304-5p	93.9586	NM_001166208
SYNPO	hsa-miR-1827	92.0891	NM_001166208
SYNPO	hsa-miR-6727-3p	84.5326	NM_001166208
SYNPO	hsa-miR-1306-5p	84.3823	NM_001166208
SYNPO	hsa-miR-3974	84.3475	NM_007286
SYNPO	hsa-miR-3616-3p	82.626	NM_007286
SYNPO	hsa-miR-4289	82.426	NM_007286
SYNPO	hsa-miR-3202	81.3428	NM_007286
SYNPO	hsa-miR-670-3p	80.7153	NM_001166208
SYNPO	hsa-miR-6085	80.0912	NM_007286
SYNPO	hsa-miR-6813-5p	80.0912	NM_007286

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Motifs and transcription factors (TFs) regulating SYNPO

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SYNPO	transfac_pro__M07260	IKZF1 (directAnnotation).
SYNPO	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).
SYNPO	transfac_pro__M01835	KLF4 (directAnnotation).
SYNPO	jaspar__MA1125.1	ZNF384 (directAnnotation).
SYNPO	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
SYNPO	transfac_pro__M07270	TEAD4 (directAnnotation).
SYNPO	metacluster_74.19	HNF1A (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."