Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYNC

Summary for SYNC

Gene information	Gene symbol	SYNC
	Ensembl ID	ENSG00000162520
	Entrez ID	81493
	Gene name	syncoilin, intermediate filament protein
	Synonyms	SYNC1\|SYNCOILIN
	Gene type	protein_coding
	UniProtAcc	Q9H7C4

Top

Dataset with differentially expressed gene: SYNC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.281903	2.02e-32

Top

Expression of SYNC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SYNC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SYNC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYNC	hsa-miR-302e	93.3092	NM_030786
SYNC	hsa-miR-1199-5p	92.0003	NM_030786
SYNC	hsa-miR-6751-3p	92.0003	NM_030786
SYNC	hsa-miR-29b-2-5p	91.2473	NM_001161708
SYNC	hsa-miR-302c-3p	90.2687	NM_030786
SYNC	hsa-miR-302b-3p	90.2687	NM_030786
SYNC	hsa-miR-302d-3p	90.2687	NM_030786
SYNC	hsa-miR-302a-3p	90.2687	NM_030786
SYNC	hsa-miR-362-5p	89.5525	NM_001161708
SYNC	hsa-miR-500b-5p	89.5525	NM_001161708
SYNC	hsa-miR-520d-3p	89.3102	NM_030786
SYNC	hsa-miR-520a-3p	89.3102	NM_030786
SYNC	hsa-miR-520b-3p	89.3102	NM_030786
SYNC	hsa-miR-373-3p	89.3102	NM_030786
SYNC	hsa-miR-520c-3p	89.3102	NM_030786
SYNC	hsa-miR-372-3p	89.3102	NM_030786
SYNC	hsa-miR-520e-3p	89.3102	NM_030786
SYNC	hsa-miR-520f-3p	88.8011	NM_030786
SYNC	hsa-miR-3121-5p	87.7074	NM_030786
SYNC	hsa-miR-4749-3p	86.8616	NM_001161708
SYNC	hsa-miR-506-5p	86.585	NM_001161708
SYNC	hsa-miR-6783-5p	86.2833	NM_030786
SYNC	hsa-miR-6764-5p	84.2711	NM_001161708
SYNC	hsa-miR-6831-3p	84.1574	NM_030786
SYNC	hsa-miR-1915-3p	84.0887	NM_001161708
SYNC	hsa-miR-335-5p	82.6484	NM_001161708
SYNC	hsa-miR-10397-5p	81.8627	NM_001161708
SYNC	hsa-miR-5586-3p	81.4768	NM_001161708
SYNC	hsa-miR-6832-5p	80.184	NM_030786

Page: 1

Top

Motifs and transcription factors (TFs) regulating SYNC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SYNC	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SYNC	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SYNC	jaspar__MA0079.5	SP1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."