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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYCP2

Summary for SYCP2

Gene information	Gene symbol	SYCP2
	Ensembl ID	ENSG00000196074
	Entrez ID	10388
	Gene name	synaptonemal complex protein 2
	Synonyms	SCP2
	Gene type	protein_coding
	UniProtAcc	Q9BX26

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Dataset with differentially expressed gene: SYCP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.07597	0.00e+00

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Expression of SYCP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SYCP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SYCP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYCP2	hsa-miR-153-5p	94.6031	NM_014258
SYCP2	hsa-miR-519d-5p	94.51	NM_014258
SYCP2	hsa-miR-4452	93.1731	NM_014258
SYCP2	hsa-miR-208a-5p	92.4362	NM_014258
SYCP2	hsa-miR-208b-5p	92.4362	NM_014258
SYCP2	hsa-miR-548n	89.481	NM_014258
SYCP2	hsa-miR-6870-3p	88.7485	NM_014258
SYCP2	hsa-miR-183-3p	88.3071	NM_014258
SYCP2	hsa-miR-580-5p	87.1929	NM_014258
SYCP2	hsa-miR-28-3p	86.9135	NM_014258
SYCP2	hsa-miR-337-3p	86.2792	NM_014258
SYCP2	hsa-miR-15a-3p	85.0808	NM_014258
SYCP2	hsa-miR-5704	84.3606	NM_014258
SYCP2	hsa-miR-577	83.3577	NM_014258
SYCP2	hsa-miR-670-3p	83.1131	NM_014258
SYCP2	hsa-miR-6892-3p	83.1061	NM_014258
SYCP2	hsa-miR-4729	80.2609	NM_014258

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Motifs and transcription factors (TFs) regulating SYCP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SYCP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SYCP2	hdpi__ETV4	ETV4 (directAnnotation).
SYCP2	metacluster_182.10	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."