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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SVIP

Summary for SVIP

Gene information	Gene symbol	SVIP
	Ensembl ID	ENSG00000198168
	Entrez ID	258010
	Gene name	small VCP interacting protein
	Synonyms	DKFZp313A2432
	Gene type	protein_coding
	UniProtAcc	Q8NHG7

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Dataset with differentially expressed gene: SVIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.422386	4.57e-18
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.279726	5.98e-42
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.276506	2.10e-15
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.451396	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.727575	1.17e-38
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.03836	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.56131	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.276085	9.16e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.365478	2.90e-14
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.271709	1.09e-04
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.326547	1.41e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.408295	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.578254	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.441817	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.547976	0.00e+00

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Expression of SVIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SVIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SVIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SVIP	hsa-miR-5011-5p	99.9587	NM_001320342
SVIP	hsa-miR-6867-5p	99.1458	NM_001320342
SVIP	hsa-miR-190a-3p	99.0506	NM_001320342
SVIP	hsa-miR-4503	97.951	NM_001320342
SVIP	hsa-miR-548an	97.4985	NM_001320340
SVIP	hsa-miR-1277-5p	97.465	NM_001320342
SVIP	hsa-miR-590-3p	96.9929	NM_001320342
SVIP	hsa-miR-4775	96.264	NM_001320342
SVIP	hsa-miR-3148	94.6347	NM_001320342
SVIP	hsa-miR-5094	93.1085	NM_001320342
SVIP	hsa-miR-5692c	91.3896	NM_001320342
SVIP	hsa-miR-5692b	91.3896	NM_001320342
SVIP	hsa-miR-34c-3p	91.2081	NM_001320342
SVIP	hsa-miR-124-3p	91.1161	NM_001320340
SVIP	hsa-miR-506-3p	91.1161	NM_001320340
SVIP	hsa-miR-4531	90.7944	NM_001320342
SVIP	hsa-miR-4276	90.7851	NM_001320342
SVIP	hsa-miR-3160-3p	89.4854	NM_001320342
SVIP	hsa-miR-4282	89.0478	NM_001320342
SVIP	hsa-miR-651-5p	88.9266	NM_001320342
SVIP	hsa-miR-656-3p	88.8906	NM_001320342
SVIP	hsa-miR-100-3p	87.6998	NM_001320342
SVIP	hsa-miR-376c-3p	87.491	NM_001320342
SVIP	hsa-miR-8069	86.5288	NM_001320342
SVIP	hsa-miR-6886-3p	85.9347	NM_001320340
SVIP	hsa-miR-12131	85.6738	NM_001320342
SVIP	hsa-miR-340-5p	85.1278	NM_001320340
SVIP	hsa-miR-606	83.6605	NM_001320342
SVIP	hsa-miR-8065	83.5089	NM_001320342
SVIP	hsa-miR-4699-3p	83.1758	NM_001320342
SVIP	hsa-miR-7113-5p	83.1234	NM_001320342
SVIP	hsa-miR-377-3p	81.8032	NM_001320342
SVIP	hsa-miR-4325	81.6708	NM_001320342
SVIP	hsa-miR-4436b-5p	81.2803	NM_001320342
SVIP	hsa-miR-3678-3p	81.2594	NM_001320340
SVIP	hsa-miR-6499-3p	80.776	NM_001320342
SVIP	hsa-miR-222-3p	80.6495	NM_001320342
SVIP	hsa-miR-221-3p	80.6495	NM_001320342
SVIP	hsa-miR-15b-5p	80.4379	NM_001320342
SVIP	hsa-miR-15a-5p	80.4379	NM_001320342
SVIP	hsa-miR-195-5p	80.4379	NM_001320342
SVIP	hsa-miR-16-5p	80.4379	NM_001320342

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Motifs and transcription factors (TFs) regulating SVIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SVIP	transfac_pro__M05628	ZNF735 (directAnnotation).
SVIP	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SVIP	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SVIP	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
SVIP	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SVIP	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SVIP	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
SVIP	taipale_tf_pairs__ERF_DLX3_RSCGGAANNNNYAATTA_CAP_repr	DLX3; ERF (directAnnotation).
SVIP	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
SVIP	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
SVIP	transfac_pro__M04748	GABPA (directAnnotation).
SVIP	transfac_pro__M05860	ZNF548 (directAnnotation).
SVIP	transfac_pro__M06331	ZNF343 (directAnnotation).
SVIP	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SVIP	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
SVIP	transfac_pro__M06104	ZNF16 (directAnnotation).
SVIP	transfac_pro__M05886	ZNF619 (directAnnotation).
SVIP	transfac_pro__M05896	ZNF713 (directAnnotation).
SVIP	transfac_public__M00114	CREB1 (directAnnotation).
SVIP	taipale_tf_pairs__GCM1_NHLH1_NCAGCTGNNNNNNNTRCGGG_CAP_repr	GCM1; NHLH1 (directAnnotation).
SVIP	swissregulon__hs__ELK1	ELK1 (directAnnotation).
SVIP	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
SVIP	cisbp__M00808	MYPOP (inferredBy_Orthology).
SVIP	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
SVIP	transfac_pro__M04950	EGR1 (directAnnotation).
SVIP	transfac_pro__M06135	ZNF28 (directAnnotation).
SVIP	metacluster_172.6	CHD2; E2F1 (directAnnotation).
SVIP	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."