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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SV2A

Summary for SV2A

Gene information	Gene symbol	SV2A
	Ensembl ID	ENSG00000159164
	Entrez ID	9900
	Gene name	synaptic vesicle glycoprotein 2A
	Synonyms	KIAA0736\|SV2
	Gene type	protein_coding
	UniProtAcc	Q7L0J3

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Dataset with differentially expressed gene: SV2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.552142	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.431246	0.00e+00

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Expression of SV2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SV2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SV2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SV2A	hsa-miR-1207-5p	94.7692	NM_014849
SV2A	hsa-miR-4763-3p	92.7055	NM_014849
SV2A	hsa-miR-4728-5p	92.0507	NM_014849
SV2A	hsa-miR-6785-5p	92.0507	NM_014849
SV2A	hsa-miR-3143	90.8353	NM_014849
SV2A	hsa-miR-6883-5p	89.2836	NM_014849
SV2A	hsa-miR-149-3p	89.2836	NM_014849
SV2A	hsa-miR-4721	88.5558	NM_014849
SV2A	hsa-miR-3202	88.5157	NM_014849
SV2A	hsa-miR-8485	88.3848	NM_014849
SV2A	hsa-miR-302c-5p	88.061	NM_014849
SV2A	hsa-miR-218-5p	86.8081	NM_014849
SV2A	hsa-miR-133b	84.8717	NM_014849
SV2A	hsa-miR-133a-3p	84.8717	NM_014849
SV2A	hsa-miR-6825-5p	81.1573	NM_014849

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Motifs and transcription factors (TFs) regulating SV2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SV2A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SV2A	jaspar__MA0079.5	SP1 (directAnnotation).
SV2A	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
SV2A	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
SV2A	metacluster_35.7	HINFP (inferredBy_Orthology).
SV2A	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SV2A	"Brivaracetam"	DB05541	small molecule
SV2A	"Levetiracetam"	DB01202	small molecule
SV2A	"Seletracetam"	DB05885	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."