Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SUPT3H

Summary for SUPT3H

Gene information	Gene symbol	SUPT3H
	Ensembl ID	ENSG00000196284
	Entrez ID	8464
	Gene name	SPT3 homolog, SAGA and STAGA complex component
	Synonyms	SPT3\|SPT3L
	Gene type	protein_coding
	UniProtAcc	O75486

Top

Dataset with differentially expressed gene: SUPT3H

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.777573	2.09e-02

Top

Expression of SUPT3H in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SUPT3H

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SUPT3H

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SUPT3H	hsa-miR-607	98.2982	NM_181356
SUPT3H	hsa-miR-3671	98.0502	NM_181356
SUPT3H	hsa-miR-3179	96.064	NM_181356
SUPT3H	hsa-miR-12136	95.2263	NM_181356
SUPT3H	hsa-miR-3163	95.078	NM_181356
SUPT3H	hsa-miR-6727-3p	91.49	NM_181356
SUPT3H	hsa-miR-6730-5p	89.7458	NM_181356
SUPT3H	hsa-miR-8078	89.2838	NM_181356
SUPT3H	hsa-miR-8069	89.1648	NM_181356
SUPT3H	hsa-miR-4722-3p	88.9852	NM_181356
SUPT3H	hsa-miR-1272	88.2942	NM_181356
SUPT3H	hsa-miR-7515	87.7394	NM_181356
SUPT3H	hsa-miR-520f-5p	86.9215	NM_181356
SUPT3H	hsa-miR-4795-3p	86.8434	NM_181356
SUPT3H	hsa-miR-548h-3p	86.0639	NM_181356
SUPT3H	hsa-miR-548d-3p	86.0639	NM_181356
SUPT3H	hsa-miR-548z	86.0639	NM_181356
SUPT3H	hsa-miR-548ac	86.0639	NM_181356
SUPT3H	hsa-miR-548bb-3p	86.0639	NM_181356
SUPT3H	hsa-miR-7845-5p	84.4818	NM_181356
SUPT3H	hsa-miR-4469	83.8687	NM_181356
SUPT3H	hsa-miR-6761-5p	83.7441	NM_181356
SUPT3H	hsa-miR-6864-5p	83.315	NM_181356
SUPT3H	hsa-miR-6815-3p	81.7616	NM_181356
SUPT3H	hsa-miR-6740-3p	81.2508	NM_181356
SUPT3H	hsa-miR-4781-3p	81.0876	NM_181356

Page: 1

Top

Motifs and transcription factors (TFs) regulating SUPT3H

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SUPT3H	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SUPT3H	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SUPT3H	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SUPT3H	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SUPT3H	transfac_pro__M04617	ZBTB7A (directAnnotation).
SUPT3H	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SUPT3H	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
SUPT3H	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SUPT3H	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SUPT3H	transfac_pro__M07387	ZBTB7A (directAnnotation).
SUPT3H	transfac_pro__M07436	WT1 (directAnnotation).
SUPT3H	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SUPT3H	transfac_pro__M00716	ZBTB14 (directAnnotation).
SUPT3H	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SUPT3H	hdpi__HIP2	UBE2K (directAnnotation).
SUPT3H	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SUPT3H	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SUPT3H	transfac_pro__M04893	TAF1 (directAnnotation).
SUPT3H	transfac_pro__M03876	ZBTB33 (directAnnotation).
SUPT3H	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SUPT3H	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SUPT3H	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SUPT3H	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SUPT3H	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."