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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SULT1A1

Summary for SULT1A1

Gene information	Gene symbol	SULT1A1
	Ensembl ID	ENSG00000196502
	Entrez ID	6817
	Gene name	sulfotransferase family 1A member 1
	Synonyms	P-PST\|STP\|STP1
	Gene type	protein_coding
	UniProtAcc	P50225

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Dataset with differentially expressed gene: SULT1A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.28497	1.01e-41
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.451039	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.339193	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.288875	6.81e-42
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.406093	7.22e-18
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.264912	8.73e-33

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Expression of SULT1A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SULT1A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SULT1A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SULT1A1	hsa-miR-130a-5p	85.3328	NM_177529

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Motifs and transcription factors (TFs) regulating SULT1A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SULT1A1	metacluster_53.2	ZNF8 (directAnnotation).
SULT1A1	transfac_pro__M06905	ZNF585B (directAnnotation).
SULT1A1	metacluster_22.25	NFE2L2 (directAnnotation).
SULT1A1	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
SULT1A1	metacluster_22.16	BACH2 (directAnnotation).
SULT1A1	metacluster_22.18	BACH2 (inferredBy_Orthology).
SULT1A1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
SULT1A1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SULT1A1	transfac_pro__M06340	ZNF790 (directAnnotation).
SULT1A1	metacluster_22.30	NFE2L2 (directAnnotation).
SULT1A1	transfac_pro__M04706	RELA (directAnnotation).
SULT1A1	metacluster_22.27	NFE2L2 (inferredBy_Orthology).
SULT1A1	metacluster_22.29	NFE2 (directAnnotation).
SULT1A1	metacluster_103.2	ZNF136; ZNF680 (directAnnotation).
SULT1A1	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
SULT1A1	metacluster_14.11	MITF; TFE3 (inferredBy_Orthology).
SULT1A1	transfac_pro__M06613	ZNF514 (directAnnotation).
SULT1A1	transfac_pro__M05475	ZBTB41 (directAnnotation).
SULT1A1	metacluster_22.17	NFE2 (directAnnotation).
SULT1A1	metacluster_22.4	MAFG (inferredBy_Orthology).
SULT1A1	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
SULT1A1	metacluster_9.47	PAX7 (inferredBy_Orthology).
SULT1A1	taipale_tf_pairs__ELK1_SPDEF_NSMGGACGGAYNTCCKSN_CAP	ELK1; SPDEF (directAnnotation).
SULT1A1	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
SULT1A1	tfdimers__MD00034	PDX1; SOX2 (directAnnotation).
SULT1A1	transfac_pro__M06313	ZNF678 (directAnnotation).
SULT1A1	metacluster_22.33	MAFK (inferredBy_Orthology).
SULT1A1	tfdimers__MD00123	E2F1; SOX17 (directAnnotation).
SULT1A1	metacluster_22.32	NFE2L2 (directAnnotation).
SULT1A1	metacluster_22.37	BACH1 (directAnnotation).
SULT1A1	metacluster_22.1	MAFF (inferredBy_Orthology).
SULT1A1	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
SULT1A1	transfac_pro__M12556	ETV4 (directAnnotation).
SULT1A1	metacluster_22.19	NFE2 (directAnnotation).
SULT1A1	metacluster_22.36	BACH2 (directAnnotation).
SULT1A1	metacluster_22.20	MAFG (directAnnotation).
SULT1A1	metacluster_26.4	CDC5L; CDC5L; CDC5L; ZNF580; ZNF580 (directAnnotation).
SULT1A1	metacluster_130.9	ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
SULT1A1	jaspar__MA1532.2	NR1D2 (directAnnotation).
SULT1A1	transfac_pro__M05595	ZNF513 (inferredBy_Orthology).
SULT1A1	metacluster_162.4	NR1D1; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR2F6; RORA; RORB; RORB; RORC; RORC (directAnnotation).
SULT1A1	transfac_pro__M06181	ZNF165 (directAnnotation).
SULT1A1	transfac_pro__M06251	ZSCAN2 (inferredBy_Orthology).
SULT1A1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
SULT1A1	tfdimers__MD00165	CRX; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
SULT1A1	taipale_tf_pairs__FOXJ2_HOXB13_TTTWATNRNMAACA_CAP_repr	FOXJ2; HOXB13 (directAnnotation).
SULT1A1	cisbp__M01815	CEBPE (inferredBy_Orthology).
SULT1A1	transfac_pro__M06949	EVX2 (directAnnotation).
SULT1A1	hdpi__ZNF695	ZNF695 (directAnnotation).
SULT1A1	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SULT1A1	"Adenosine 3',5'-diphosphate"	DB01812	small molecule
SULT1A1	"P-Nitrophenol"	DB04417	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."