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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SUDS3

Summary for SUDS3

Gene information	Gene symbol	SUDS3
	Ensembl ID	ENSG00000111707
	Entrez ID	64426
	Gene name	SDS3 homolog, SIN3A corepressor complex component
	Synonyms	FLJ00052\|SAP45\|SDS3
	Gene type	protein_coding
	UniProtAcc	Q9H7L9

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Dataset with differentially expressed gene: SUDS3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.328471	1.75e-13
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.428952	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.287306	0.00e+00

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Expression of SUDS3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SUDS3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SUDS3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SUDS3	hsa-miR-9902	97.9751	NM_022491
SUDS3	hsa-miR-519e-5p	93.9773	NM_022491
SUDS3	hsa-miR-6770-5p	92.9051	NM_022491
SUDS3	hsa-miR-515-5p	92.5939	NM_022491
SUDS3	hsa-miR-224-5p	92.329	NM_022491
SUDS3	hsa-miR-4482-3p	91.189	NM_022491
SUDS3	hsa-miR-875-3p	90.3742	NM_022491
SUDS3	hsa-miR-125b-2-3p	88.1629	NM_022491
SUDS3	hsa-miR-10527-5p	87.7674	NM_022491
SUDS3	hsa-miR-1285-3p	87.118	NM_022491
SUDS3	hsa-miR-1299	86.4217	NM_022491
SUDS3	hsa-miR-1827	84.971	NM_022491
SUDS3	hsa-miR-4451	84.4625	NM_022491
SUDS3	hsa-miR-3613-3p	84.0616	NM_022491
SUDS3	hsa-miR-10b-3p	83.9459	NM_022491
SUDS3	hsa-miR-874-5p	83.9358	NM_022491
SUDS3	hsa-miR-548p	83.5937	NM_022491
SUDS3	hsa-miR-619-5p	83.5188	NM_022491
SUDS3	hsa-miR-6506-5p	83.5188	NM_022491
SUDS3	hsa-miR-1178-5p	83.1691	NM_022491
SUDS3	hsa-miR-6128	82.5934	NM_022491
SUDS3	hsa-miR-6837-3p	82.5448	NM_022491
SUDS3	hsa-miR-6882-5p	82.5366	NM_022491
SUDS3	hsa-miR-4520-2-3p	82.2907	NM_022491
SUDS3	hsa-miR-5189-5p	82.0628	NM_022491
SUDS3	hsa-miR-4705	81.933	NM_022491
SUDS3	hsa-miR-6771-3p	81.7963	NM_022491
SUDS3	hsa-miR-4772-3p	80.6543	NM_022491

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Motifs and transcription factors (TFs) regulating SUDS3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SUDS3	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SUDS3	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SUDS3	jaspar__MA1483.2	ELF2 (directAnnotation).
SUDS3	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
SUDS3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SUDS3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
SUDS3	cisbp__M08198	ELF1 (directAnnotation).
SUDS3	jaspar__MA1933.1	SREBF2 (directAnnotation).
SUDS3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SUDS3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SUDS3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SUDS3	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SUDS3	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SUDS3	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
SUDS3	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
SUDS3	metacluster_161.4	LHX9 (directAnnotation).
SUDS3	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
SUDS3	metacluster_161.3	LHX9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."