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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SUCLA2

Summary for SUCLA2

Gene information	Gene symbol	SUCLA2
	Ensembl ID	ENSG00000136143
	Entrez ID	8803
	Gene name	succinate-CoA ligase ADP-forming subunit beta
	Synonyms	LINC00444
	Gene type	protein_coding
	UniProtAcc	Q9P2R7

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Dataset with differentially expressed gene: SUCLA2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.492494	7.43e-44
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.316889	1.11e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.820546	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.327056	1.10e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.569794	0.00e+00

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Expression of SUCLA2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SUCLA2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SUCLA2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SUCLA2	hsa-miR-580-5p	99.0635	NM_003850
SUCLA2	hsa-miR-3671	91.9581	NM_003850
SUCLA2	hsa-miR-4433b-3p	91.0344	NM_003850
SUCLA2	hsa-miR-12119	90.7945	NM_003850
SUCLA2	hsa-miR-10522-5p	89.753	NM_003850
SUCLA2	hsa-miR-96-3p	89.1393	NM_003850
SUCLA2	hsa-miR-144-3p	87.5673	NM_003850
SUCLA2	hsa-miR-532-5p	87.4031	NM_003850
SUCLA2	hsa-miR-630	86.428	NM_003850
SUCLA2	hsa-miR-186-5p	86.1534	NM_003850
SUCLA2	hsa-miR-887-5p	86.081	NM_003850
SUCLA2	hsa-miR-4790-3p	85.2187	NM_003850
SUCLA2	hsa-miR-6788-5p	82.5043	NM_003850
SUCLA2	hsa-miR-30c-2-3p	82.5043	NM_003850
SUCLA2	hsa-miR-30c-1-3p	82.5043	NM_003850
SUCLA2	hsa-miR-4744	82.0374	NM_003850
SUCLA2	hsa-miR-3185	80.9434	NM_003850
SUCLA2	hsa-miR-16-1-3p	80.8768	NM_003850
SUCLA2	hsa-miR-6507-5p	80.5767	NM_003850

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Motifs and transcription factors (TFs) regulating SUCLA2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SUCLA2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
SUCLA2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SUCLA2	metacluster_81.7	CREB1 (directAnnotation).
SUCLA2	transfac_pro__M00492	STAT1 (directAnnotation).
SUCLA2	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
SUCLA2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."