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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STYX

Summary for STYX

Gene information	Gene symbol	STYX
	Ensembl ID	ENSG00000198252
	Entrez ID	6815
	Gene name	serine/threonine/tyrosine interacting protein
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q8WUJ0

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Dataset with differentially expressed gene: STYX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.315029	0.00e+00

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Expression of STYX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STYX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STYX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STYX	hsa-miR-6828-5p	99.1612	NM_001130701
STYX	hsa-miR-5011-5p	98.9547	NM_145251
STYX	hsa-miR-559	97.9417	NM_001130701
STYX	hsa-miR-548b-5p	97.049	NM_001130701
STYX	hsa-miR-548h-5p	97.049	NM_001130701
STYX	hsa-miR-548am-5p	97.049	NM_001130701
STYX	hsa-miR-548as-5p	97.049	NM_001130701
STYX	hsa-miR-548ay-5p	97.049	NM_001130701
STYX	hsa-miR-548ae-5p	97.049	NM_001130701
STYX	hsa-miR-548bb-5p	97.049	NM_001130701
STYX	hsa-miR-548d-5p	97.049	NM_001130701
STYX	hsa-miR-548ad-5p	97.049	NM_001130701
STYX	hsa-miR-548c-5p	97.049	NM_001130701
STYX	hsa-miR-548o-5p	97.049	NM_001130701
STYX	hsa-miR-548y	97.049	NM_001130701
STYX	hsa-miR-548a-5p	97.049	NM_001130701
STYX	hsa-miR-548ak	97.049	NM_001130701
STYX	hsa-miR-548i	97.049	NM_001130701
STYX	hsa-miR-548ar-5p	97.049	NM_001130701
STYX	hsa-miR-548ab	97.049	NM_001130701
STYX	hsa-miR-548au-5p	97.049	NM_001130701
STYX	hsa-miR-548ap-5p	97.049	NM_001130701
STYX	hsa-miR-548j-5p	97.049	NM_001130701
STYX	hsa-miR-548w	97.049	NM_001130701
STYX	hsa-miR-548aq-5p	96.4105	NM_001130701
STYX	hsa-miR-3678-3p	95.9673	NM_001130701
STYX	hsa-miR-3613-3p	94.3184	NM_001130701
STYX	hsa-miR-203b-3p	93.5322	NM_145251
STYX	hsa-miR-299-5p	93.4617	NM_145251
STYX	hsa-miR-4773	93.4133	NM_001130701
STYX	hsa-miR-498-5p	92.9155	NM_001130701
STYX	hsa-miR-1297	92.8509	NM_001130701
STYX	hsa-miR-548p	92.2035	NM_001130701
STYX	hsa-miR-380-3p	92.1754	NM_145251
STYX	hsa-miR-6758-5p	91.9322	NM_145251
STYX	hsa-miR-374a-5p	91.8328	NM_145251
STYX	hsa-miR-6856-5p	91.7079	NM_145251
STYX	hsa-miR-6734-3p	91.5532	NM_145251
STYX	hsa-miR-4804-3p	91.4648	NM_001130701
STYX	hsa-miR-26a-5p	91.345	NM_001130701
STYX	hsa-miR-26b-5p	91.345	NM_001130701
STYX	hsa-miR-1273h-3p	91.0807	NM_001130701
STYX	hsa-miR-190a-3p	90.9389	NM_145251
STYX	hsa-miR-154-3p	90.5948	NM_145251
STYX	hsa-miR-487a-3p	90.5948	NM_145251
STYX	hsa-miR-22-3p	90.486	NM_001130701
STYX	hsa-miR-374b-5p	89.1497	NM_145251
STYX	hsa-miR-4465	88.9663	NM_001130701
STYX	hsa-miR-92b-3p	88.5102	NM_001130701
STYX	hsa-miR-32-5p	88.5102	NM_001130701

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Motifs and transcription factors (TFs) regulating STYX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STYX	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
STYX	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
STYX	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
STYX	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
STYX	jaspar__MA1122.1	TFDP1 (directAnnotation).
STYX	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."