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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STX7

Summary for STX7

Gene information	Gene symbol	STX7
	Ensembl ID	ENSG00000079950
	Entrez ID	8417
	Gene name	syntaxin 7
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O15400

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Dataset with differentially expressed gene: STX7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.386629	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.29349	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.09502	6.85e-07
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.275974	3.27e-09
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.316799	0.00e+00
GSE152469	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	NA	Malignant cells	-0.261435	0.00e+00

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Expression of STX7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STX7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STX7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STX7	hsa-miR-3646	98.9759	NM_003569
STX7	hsa-miR-3613-3p	98.3809	NM_003569
STX7	hsa-miR-580-3p	95.3829	NM_003569
STX7	hsa-miR-5692a	90.2337	NM_003569
STX7	hsa-miR-4672	88.8699	NM_003569
STX7	hsa-miR-6502-3p	88.4762	NM_003569
STX7	hsa-miR-3074-3p	87.2122	NM_003569
STX7	hsa-miR-16-1-3p	86.7041	NM_003569
STX7	hsa-miR-7844-5p	86.5705	NM_003569
STX7	hsa-miR-590-3p	85.6277	NM_003569
STX7	hsa-miR-4671-3p	85.5771	NM_003569
STX7	hsa-miR-128-3p	84.7373	NM_003569
STX7	hsa-miR-216a-3p	84.7373	NM_003569
STX7	hsa-miR-499b-5p	84.5783	NM_003569
STX7	hsa-miR-6510-5p	84.2564	NM_003569
STX7	hsa-miR-497-3p	84.2131	NM_003569
STX7	hsa-miR-302a-5p	83.8723	NM_003569
STX7	hsa-miR-6833-5p	82.5598	NM_003569
STX7	hsa-miR-10398-5p	82.2045	NM_003569
STX7	hsa-miR-3681-3p	80.8928	NM_003569
STX7	hsa-miR-3163	80.6045	NM_003569
STX7	hsa-miR-1279	80.434	NM_003569
STX7	hsa-miR-215-5p	80.2734	NM_003569
STX7	hsa-miR-192-5p	80.1823	NM_003569
STX7	hsa-miR-32-3p	80.0428	NM_003569

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Motifs and transcription factors (TFs) regulating STX7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STX7	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
STX7	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
STX7	transfac_pro__M04862	NRF1 (directAnnotation).
STX7	taipale_tf_pairs__ETV5_FOXO1_RNCGGATGTTKWN_CAP	ETV5; FOXO1 (directAnnotation).
STX7	taipale_tf_pairs__E2F3_FOXI1_NNMCACCGCGCCCMN_CAP_repr	E2F3; FOXI1 (directAnnotation).
STX7	transfac_pro__M06363	ZNF730 (directAnnotation).
STX7	transfac_pro__M06388	ZNF677 (directAnnotation).
STX7	transfac_pro__M06693	ZNF331 (directAnnotation).
STX7	metacluster_131.5	KLF17 (directAnnotation).
STX7	tfdimers__MD00482	POU5F1; RUNX3 (directAnnotation).
STX7	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_2	SPIB; TEAD4 (directAnnotation).
STX7	transfac_pro__M05799	ZNF605 (directAnnotation).
STX7	metacluster_35.9	ZNF860; ZNF860 (directAnnotation).
STX7	metacluster_3.8	SP5 (inferredBy_Orthology).
STX7	transfac_pro__M06386	ZNF836 (directAnnotation).
STX7	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
STX7	taipale_tf_pairs__TEAD4_EOMES_RGGTGTNNNNNNNNGAATGYN_CAP_repr	EOMES; TEAD4 (directAnnotation).
STX7	metacluster_144.9	SP2 (directAnnotation).
STX7	transfac_pro__M05986	ZNF394 (inferredBy_Orthology).
STX7	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
STX7	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
STX7	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
STX7	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
STX7	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
STX7	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
STX7	metacluster_177.7	ZBTB18; ZBTB18; ZBTB18; ZBTB42 (directAnnotation).
STX7	hocomoco__ZBT14_HUMAN.H11MO.0.C	ZBTB14 (directAnnotation).
STX7	kznf__ZNF26_Imbeault2017_OM_MEME	ZNF26 (directAnnotation).
STX7	nitta__Ets98B_TTCTAG20NTA_KI_TAMCGGATGC_m2_c4	SPDEF (inferredBy_Orthology).
STX7	taipale_cyt_meth__KLF3_NRCCGCAGCCCN_FL_meth_repr	KLF3 (directAnnotation).
STX7	metacluster_45.4	E2F2 (directAnnotation).
STX7	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
STX7	kznf__ZNF669_Najafabadi2015_ChIP-seq	ZNF669 (directAnnotation).
STX7	hdpi__HTATIP2	HTATIP2 (directAnnotation).
STX7	tfdimers__MD00553	FOXG1; FOXO1; RUNX3 (directAnnotation).
STX7	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
STX7	hdpi__NRL	NRL (directAnnotation).
STX7	taipale_tf_pairs__E2F1_NHLH1_SGCGCCNNNNNNNNNNNNCAGCTGNN_CAP_repr	E2F1; NHLH1 (directAnnotation).
STX7	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
STX7	cisbp__M00968	MTF2 (directAnnotation).
STX7	hdpi__FEZF2	FEZF2 (directAnnotation).
STX7	transfac_pro__M07310	SP5 (directAnnotation).
STX7	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
STX7	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
STX7	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
STX7	metacluster_155.11	SPZ1 (directAnnotation).
STX7	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
STX7	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
STX7	hdpi__HIP2	UBE2K (directAnnotation).
STX7	hdpi__ZNF304	ZNF304 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."