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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STX2

Summary for STX2

Gene information	Gene symbol	STX2
	Ensembl ID	ENSG00000111450
	Entrez ID	2054
	Gene name	syntaxin 2
	Synonyms	EPIM\|EPM\|STX2A\|STX2B\|STX2C
	Gene type	protein_coding
	UniProtAcc	P32856

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Dataset with differentially expressed gene: STX2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.40252	0.00e+00

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Expression of STX2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STX2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STX2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STX2	hsa-miR-4719	95.7831	NM_194356
STX2	hsa-miR-30b-5p	95.3597	NM_194356
STX2	hsa-miR-30e-5p	95.3597	NM_194356
STX2	hsa-miR-30d-5p	95.3597	NM_194356
STX2	hsa-miR-30c-5p	95.3597	NM_194356
STX2	hsa-miR-30a-5p	95.3597	NM_194356
STX2	hsa-miR-200a-3p	93.8491	NM_194356
STX2	hsa-miR-141-3p	93.8491	NM_194356
STX2	hsa-miR-3922-5p	91.1118	NM_194356
STX2	hsa-miR-4495	90.0405	NM_194356
STX2	hsa-miR-940	88.8066	NM_001980
STX2	hsa-miR-6808-5p	88.8066	NM_001980
STX2	hsa-miR-6893-5p	88.8066	NM_001980
STX2	hsa-miR-6715b-3p	88.5518	NM_001980
STX2	hsa-miR-7975	87.9358	NM_001980
STX2	hsa-miR-6785-5p	85.5721	NM_001980
STX2	hsa-miR-4728-5p	85.5721	NM_001980
STX2	hsa-miR-4694-5p	85.3643	NM_001980
STX2	hsa-miR-4753-5p	85.0915	NM_194356
STX2	hsa-miR-518c-5p	85.0706	NM_001980
STX2	hsa-miR-4457	84.8633	NM_194356
STX2	hsa-miR-6129	84.7207	NM_001980
STX2	hsa-miR-6130	84.7207	NM_001980
STX2	hsa-miR-6133	84.7207	NM_001980
STX2	hsa-miR-4510	84.7207	NM_001980
STX2	hsa-miR-6127	84.7207	NM_001980
STX2	hsa-miR-149-3p	84.4307	NM_001980
STX2	hsa-miR-6883-5p	84.4307	NM_001980
STX2	hsa-miR-4684-5p	83.3995	NM_001980
STX2	hsa-miR-371b-5p	82.038	NM_001980
STX2	hsa-miR-373-5p	82.038	NM_001980
STX2	hsa-miR-616-5p	82.038	NM_001980
STX2	hsa-miR-6827-3p	81.52	NM_001980
STX2	hsa-miR-384	81.5195	NM_001980
STX2	hsa-miR-3180-5p	81.4105	NM_001980
STX2	hsa-miR-3667-3p	81.0283	NM_001980
STX2	hsa-miR-3613-3p	80.115	NM_001980

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Motifs and transcription factors (TFs) regulating STX2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STX2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
STX2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
STX2	transfac_pro__M04866	HDAC2 (directAnnotation).
STX2	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."