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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STX16

Summary for STX16

Gene information	Gene symbol	STX16
	Ensembl ID	ENSG00000124222
	Entrez ID	8675
	Gene name	syntaxin 16
	Synonyms	hsyn16\|SYN-16\|SYN16
	Gene type	protein_coding
	UniProtAcc	O14662

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Dataset with differentially expressed gene: STX16

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.332757	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.25953	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.290286	1.25e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.5906	0.00e+00

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Expression of STX16 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STX16

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STX16

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STX16	hsa-miR-299-5p	95.5657	NM_001134773
STX16	hsa-miR-29b-2-5p	94.9351	NM_001134773
STX16	hsa-miR-548ac	94.0829	NM_001134773
STX16	hsa-miR-548z	94.0829	NM_001134773
STX16	hsa-miR-548bb-3p	94.0829	NM_001134773
STX16	hsa-miR-548h-3p	94.0829	NM_001134773
STX16	hsa-miR-548d-3p	94.0829	NM_001134773
STX16	hsa-miR-7-2-3p	93.479	NM_001001433
STX16	hsa-miR-7-1-3p	93.479	NM_001001433
STX16	hsa-miR-8069	93.1643	NM_001134773
STX16	hsa-miR-556-3p	92.8564	NM_001001433
STX16	hsa-miR-30c-5p	91.7508	NM_001134773
STX16	hsa-miR-30d-5p	91.7508	NM_001134773
STX16	hsa-miR-30b-5p	91.7508	NM_001134773
STX16	hsa-miR-30a-5p	91.7508	NM_001134773
STX16	hsa-miR-30e-5p	91.7508	NM_001134773
STX16	hsa-miR-6124	91.6657	NM_001134773
STX16	hsa-miR-29a-3p	91.1011	NM_001001433
STX16	hsa-miR-29b-3p	91.1011	NM_001001433
STX16	hsa-miR-29c-3p	91.1011	NM_001001433
STX16	hsa-miR-551b-5p	90.7128	NM_001001433
STX16	hsa-miR-212-3p	89.7653	NM_001134773
STX16	hsa-miR-132-3p	89.7653	NM_001134773
STX16	hsa-miR-767-5p	89.6922	NM_001001433
STX16	hsa-miR-302f	89.5358	NM_001001433
STX16	hsa-miR-1263	88.9765	NM_001001433
STX16	hsa-let-7c-3p	88.8975	NM_001134773
STX16	hsa-miR-6744-3p	88.7201	NM_001134773
STX16	hsa-miR-4757-5p	88.7201	NM_001134773
STX16	hsa-miR-12136	88.2777	NM_001134773
STX16	hsa-miR-4282	87.9796	NM_001134773
STX16	hsa-miR-5692a	86.2695	NM_001001433
STX16	hsa-miR-6762-3p	86.2139	NM_001134773
STX16	hsa-miR-3976	84.9697	NM_001134773
STX16	hsa-miR-4503	84.6247	NM_001134773
STX16	hsa-miR-4714-5p	84.6014	NM_001134773
STX16	hsa-miR-5689	83.1378	NM_001134773
STX16	hsa-miR-9985	83.0347	NM_001134773
STX16	hsa-miR-27b-3p	83.0347	NM_001134773
STX16	hsa-miR-27a-3p	83.0347	NM_001134773
STX16	hsa-miR-3148	82.6132	NM_001134773
STX16	hsa-miR-4256	82.2255	NM_001001433
STX16	hsa-miR-11181-5p	82.2188	NM_001001433
STX16	hsa-miR-6809-3p	82.1807	NM_001001433
STX16	hsa-miR-518c-5p	82.0378	NM_001134773
STX16	hsa-miR-190b-3p	81.9007	NM_001134773
STX16	hsa-miR-3202	80.9292	NM_001134773
STX16	hsa-miR-545-5p	80.8978	NM_001134773
STX16	hsa-miR-660-5p	80.6351	NM_001001433

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Motifs and transcription factors (TFs) regulating STX16

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STX16	tfdimers__MD00465	CRX; IKZF1 (directAnnotation).
STX16	transfac_pro__M06602	ZNF669 (directAnnotation).
STX16	metacluster_22.39	NFE2L2 (directAnnotation).
STX16	jaspar__MA0079.5	SP1 (directAnnotation).
STX16	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
STX16	transfac_pro__M01253	CNOT3 (directAnnotation).
STX16	transfac_pro__M04817	ZBTB33 (directAnnotation).
STX16	transfac_pro__M03806	ZBTB7C (directAnnotation).
STX16	transfac_pro__M04916	TAF1 (directAnnotation).
STX16	jaspar__MA1650.1	ZBTB14 (directAnnotation).
STX16	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
STX16	hdpi__HIP2	UBE2K (directAnnotation).
STX16	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
STX16	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
STX16	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
STX16	cisbp__M00788	ZFY (inferredBy_Orthology).
STX16	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
STX16	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
STX16	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
STX16	metacluster_175.1	ZNF283 (directAnnotation).
STX16	metacluster_7.13	ZFX (directAnnotation).
STX16	hdpi__FEZF2	FEZF2 (directAnnotation).
STX16	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
STX16	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
STX16	swissregulon__hs__KLF6	KLF6 (directAnnotation).
STX16	transfac_pro__M02898	SMAD3 (directAnnotation).
STX16	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
STX16	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
STX16	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
STX16	metacluster_198.3	ZFP64 (directAnnotation).
STX16	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
STX16	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
STX16	transfac_pro__M04617	ZBTB7A (directAnnotation).
STX16	metacluster_155.11	SPZ1 (directAnnotation).
STX16	metacluster_160.20	JUND; PRDM15 (directAnnotation).
STX16	tfdimers__MD00167	HIC1; MAFA (directAnnotation).
STX16	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
STX16	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."