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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STT3B

Summary for STT3B

Gene information	Gene symbol	STT3B
	Ensembl ID	ENSG00000163527
	Entrez ID	201595
	Gene name	STT3 oligosaccharyltransferase complex catalytic subunit B
	Synonyms	FLJ90106\|SIMP\|STT3-B
	Gene type	protein_coding
	UniProtAcc	Q8TCJ2

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Dataset with differentially expressed gene: STT3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.50079	1.05e-18
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.472992	1.26e-37
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.417313	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.312303	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.376065	0.00e+00

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Expression of STT3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STT3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STT3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STT3B	hsa-miR-494-3p	98.2661	NM_178862
STT3B	hsa-miR-543	97.5294	NM_178862
STT3B	hsa-miR-3977	97.3034	NM_178862
STT3B	hsa-miR-12122	94.7985	NM_178862
STT3B	hsa-miR-320e	94.7839	NM_178862
STT3B	hsa-miR-3662	93.7455	NM_178862
STT3B	hsa-miR-105-5p	93.6202	NM_178862
STT3B	hsa-miR-7853-5p	93.6202	NM_178862
STT3B	hsa-miR-10393-5p	92.8487	NM_178862
STT3B	hsa-miR-23a-3p	92.5975	NM_178862
STT3B	hsa-miR-23c	92.5975	NM_178862
STT3B	hsa-miR-23b-3p	92.5975	NM_178862
STT3B	hsa-miR-6124	92.4442	NM_178862
STT3B	hsa-miR-9-5p	90.9982	NM_178862
STT3B	hsa-miR-4330	90.7375	NM_178862
STT3B	hsa-miR-6500-3p	89.6968	NM_178862
STT3B	hsa-miR-4671-3p	89.6501	NM_178862
STT3B	hsa-miR-129-2-3p	89.1126	NM_178862
STT3B	hsa-miR-129-1-3p	89.1126	NM_178862
STT3B	hsa-miR-3671	89.0703	NM_178862
STT3B	hsa-miR-95-5p	87.3424	NM_178862
STT3B	hsa-miR-137-3p	87.0279	NM_178862
STT3B	hsa-miR-5571-5p	86.3112	NM_178862
STT3B	hsa-miR-3973	86.2864	NM_178862
STT3B	hsa-miR-4673	86.2192	NM_178862
STT3B	hsa-miR-1304-3p	84.889	NM_178862
STT3B	hsa-miR-4645-5p	84.698	NM_178862
STT3B	hsa-miR-3163	84.4728	NM_178862
STT3B	hsa-miR-4659a-5p	84.3442	NM_178862
STT3B	hsa-miR-3650	83.5927	NM_178862
STT3B	hsa-miR-4659b-5p	83.2224	NM_178862
STT3B	hsa-miR-4289	82.8594	NM_178862
STT3B	hsa-miR-3914	82.648	NM_178862
STT3B	hsa-miR-136-5p	82.5804	NM_178862
STT3B	hsa-miR-4780	81.9496	NM_178862
STT3B	hsa-miR-30a-5p	81.4841	NM_178862
STT3B	hsa-miR-30d-5p	81.4841	NM_178862
STT3B	hsa-miR-30c-5p	81.4841	NM_178862
STT3B	hsa-miR-30b-5p	81.4841	NM_178862
STT3B	hsa-miR-30e-5p	81.4841	NM_178862
STT3B	hsa-miR-548an	80.8003	NM_178862

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Motifs and transcription factors (TFs) regulating STT3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STT3B	metacluster_7.13	ZFX (directAnnotation).
STT3B	cisbp__M01863	ZNF711 (inferredBy_Orthology).
STT3B	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
STT3B	metacluster_151.2	ZNF23 (directAnnotation).
STT3B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
STT3B	transfac_pro__M05479	ZNF580 (directAnnotation).
STT3B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
STT3B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
STT3B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
STT3B	hdpi__ETV4	ETV4 (directAnnotation).
STT3B	jaspar__MA0748.2	YY2 (directAnnotation).
STT3B	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
STT3B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
STT3B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
STT3B	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
STT3B	jaspar__MA0079.5	SP1 (directAnnotation).
STT3B	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
STT3B	transfac_pro__M04826	EP300 (directAnnotation).
STT3B	transfac_pro__M06660	ZNF670 (directAnnotation).
STT3B	taipale_tf_pairs__ELK1_PAX5_RSCGGAACYACGCWYSANTG_CAP_repr	ELK1; PAX5 (directAnnotation).
STT3B	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
STT3B	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
STT3B	transfac_pro__M05930	ZNF286A (directAnnotation).
STT3B	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
STT3B	metacluster_16.7	SOX10; SOX11; SOX14; SOX14; SOX15; SOX18; SOX2; SOX2; SOX21; SOX21; SOX21; SOX7; SOX7; SOX7; SOX8; SOX8; SOX9; SRY (directAnnotation). SOX1; SOX1; SOX10; SOX21; SOX3 (inferredBy_Orthology).
STT3B	transfac_public__M00039	CREB1 (directAnnotation).
STT3B	transfac_pro__M00691	ATF1 (directAnnotation).
STT3B	jaspar__MA0039.4	KLF4 (directAnnotation).
STT3B	transfac_pro__M04746	E2F1 (directAnnotation).
STT3B	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
STT3B	transfac_pro__M04595	SALL2 (directAnnotation).
STT3B	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
STT3B	metacluster_79.34	GATA2; GATA5 (directAnnotation).
STT3B	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
STT3B	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."