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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STT3A

Summary for STT3A

Gene information	Gene symbol	STT3A
	Ensembl ID	ENSG00000134910
	Entrez ID	3703
	Gene name	STT3 oligosaccharyltransferase complex catalytic subunit A
	Synonyms	ITM1\|MGC9042\|STT3-A\|TMC
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: STT3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.376199	1.90e-27
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.277702	0.00e+00

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Expression of STT3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STT3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STT3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STT3A	hsa-miR-548c-3p	97.6309	NM_001278503
STT3A	hsa-miR-1323	96.8578	NM_001278503
STT3A	hsa-miR-124-3p	95.6765	NM_001278503
STT3A	hsa-miR-506-3p	95.6765	NM_001278503
STT3A	hsa-miR-1279	94.9962	NM_001278503
STT3A	hsa-miR-664b-3p	94.2901	NM_001278503
STT3A	hsa-miR-548o-3p	94.1253	NM_001278503
STT3A	hsa-miR-12123	94.0629	NM_001278503
STT3A	hsa-miR-217-5p	92.6791	NM_001278503
STT3A	hsa-miR-6807-3p	92.6791	NM_001278503
STT3A	hsa-miR-579-3p	92.0044	NM_001278503
STT3A	hsa-miR-548av-3p	90.7535	NM_001278503
STT3A	hsa-miR-664a-3p	90.6396	NM_001278503
STT3A	hsa-miR-340-5p	88.9187	NM_001278503
STT3A	hsa-miR-4255	88.5141	NM_001278503
STT3A	hsa-miR-5582-5p	87.7719	NM_001278503
STT3A	hsa-miR-3910	87.3112	NM_001278503
STT3A	hsa-miR-3714	87.3112	NM_001278503
STT3A	hsa-miR-190a-5p	86.7299	NM_001278503
STT3A	hsa-miR-649	86.5517	NM_001278503
STT3A	hsa-miR-6784-3p	85.8181	NM_001278503
STT3A	hsa-miR-190b-5p	83.8265	NM_001278503
STT3A	hsa-miR-582-3p	83.4711	NM_001278503
STT3A	hsa-miR-5582-3p	82.0385	NM_001278503
STT3A	hsa-miR-5002-5p	82.0156	NM_001278503
STT3A	hsa-miR-607	81.0122	NM_001278503
STT3A	hsa-miR-6862-3p	80.9618	NM_001278503
STT3A	hsa-miR-660-3p	80.11	NM_001278503

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Motifs and transcription factors (TFs) regulating STT3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STT3A	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
STT3A	hdpi__TP73	TP73 (directAnnotation).
STT3A	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
STT3A	transfac_pro__M04862	NRF1 (directAnnotation).
STT3A	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
STT3A	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
STT3A	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
STT3A	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
STT3A	tfdimers__MD00567	IKZF2 (directAnnotation).
STT3A	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."